Synthesis of peptide-grafted comb polypeptides via polymerisation of NCA-peptides.

Hiroshi Enomoto; Benjamin Nottelet; Al Halifa Soultan; Christine Enjalbal; Mathieu Dupré; Julien Tailhades; Jean Coudane; Gilles Subra; Jean Martinez; Muriel Amblard

doi:10.1039/c2cc37597d

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Synthesis of peptide-grafted comb polypeptides via polymerisation of NCA-peptides.

Journal article

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Synthesis of peptide-grafted comb polypeptides via polymerisation of NCA-peptides.

Hiroshi Enomoto, Benjamin Nottelet, Al Halifa Soultan, Christine Enjalbal, Mathieu Dupré, Julien Tailhades, Jean Coudane, Gilles Subra, Jean Martinez and Muriel Amblard

Chemical Communications, Vol.49(4), pp.409-411

07/01/2013

DOI: https://doi.org/10.1039/c2cc37597d

PMID: 23187977

Abstract

Amino Acids

Anhydrides

Ion Exchanges Resins

Molecular Structure

Peptides

Polymerization

A straightforward synthesis of comb-polypeptides of repeated peptide sequences was developed. These polypeptides were obtained by ROP of defined NCA without any post-polymerization grafting. The key to this strategy relies on the preparation of pure NCA bearing a peptide sequence on its side chain, by an original solid supported methodology.

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Title: Synthesis of peptide-grafted comb polypeptides via polymerisation of NCA-peptides.
Creators - without role: Hiroshi Enomoto - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Benjamin Nottelet - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Al Halifa Soultan - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Christine Enjalbal - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Mathieu Dupré - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Julien Tailhades - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Jean Coudane - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Gilles Subra - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Jean Martinez - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Muriel Amblard - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: Chemical Communications, Vol.49(4), pp.409-411
Identifiers: 9942654009311
Academic Unit: Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-01091002