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Synthesis of peptide analogue including a C-phosphono moiety. Synthesis of N- and O-protected alafosfaline
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Synthesis of peptide analogue including a C-phosphono moiety. Synthesis of N- and O-protected alafosfaline

C Grison, C Comoy et P Coutrot
L'Actualité chimique, (10), pp.38-48
01/10/2001

Résumé

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
In the present article, a synthesis of N- and O-protected Alafosfaline was described. The expected C-phosphonopeptide was obtained by using a very efficient reactionnal way in good yield starting from 2-dialkylphosphonopropanoic acid. Analyses of intermediates and adducts were performed and involved the use of techniques such as Infra Red and NMR H-1, C-13 or P-31 spectroscopies, thin layer chromatography [1].

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