Abstract
Racemic synthesis of novel 3' -methyl-5' -norcarbocyclic nucleoside phosphonates 1aec and 2 was performed using 4-hydroxy-2-methylcyclo-pent-2-enone as starting material. Direct coupling of the heterocyclic base involved a Mitsunobu reaction as key step. The compounds were evaluated for their antiviral properties, but none of them showed significant activity.