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Synthesis of new triheterocyclic compounds, precursors of biheterocyclicaminoacids
Journal article   Open access   Peer reviewed

Synthesis of new triheterocyclic compounds, precursors of biheterocyclicaminoacids

Valérie Rolland, Younas Aouine, Anouar Alami, Abdelrhani Elachqar, A. Kerbal, B. Labriti and Jean Martinez
Journal Marocain de Chimie Hétérocyclique, Vol.7(1), pp.44-49
12/2008

Abstract

N-alkylation 1 3-dipolar cycloaddition oxazolinic precursors N-propargyl
Heterocyclic alkynes 1-2 were obtained easily in good yield by N-alkylation of carbazole orbenzimidazole with propargyl bromide. The 1,3-dipolar cycloaddition of these alkynes with the 4-azidomethyl-4-methyl-2-phenyloxazoline 3 afford new oxazolinic derivatives 4-5, precursors ofbiheterocyclic aminoalcohols, aminoaldehydes and amino acids.
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