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Synthesis of enantiomerically pure (3R,4R,5R)-4-hydroxy isoleucine lactone
Article de revue   Avec comité de lecture

Synthesis of enantiomerically pure (3R,4R,5R)-4-hydroxy isoleucine lactone

Tarek Kassem, Jonhy Wehbe, Valérie Rolland, Marc Rolland, Marie-Louise Roumestant et Jean Martinez
Tetrahedron: asymmetry, Vol.12(19), pp.2657-2661
30/10/2001
DOI: https://doi.org/10.1016/S0957-4166(01)00465-7

Résumé

Chemical Sciences Medicinal Chemistry Organic chemistry
A short four-step synthesis of (3R,4R,5R)-4-hydroxyisoleucine lactone with total control of stereochemistry is reported, the key intermediate being the didehydroamino acid derivative arising from an aldol dehydration reaction between a glycine anion equivalent and butan-2,3-dione.

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