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Synthesis of difluorinated carbocyclic analogues of 5-deoxypentofuranoses
Article de revue   Avec comité de lecture

Synthesis of difluorinated carbocyclic analogues of 5-deoxypentofuranoses

Gaëlle Fourrière, Jérôme Lalot, Nathalie Van Hijfte, Jean-Charles Quirion et Eric Leclerc
Tetrahedron letters, Vol.50(50), pp.7048-7050
16/12/2009
DOI: https://doi.org/10.1016/j.tetlet.2009.09.170

Résumé

Carbasugars Fluorine Nucleosides Radical cyclization
The synthesis of difluorinated carbocyclic analogues of 5-deoxypentofuranoses is described. The sequence involves an addition of PhSeCF 2TMS to carbohydrate-derived aldehydes followed by a radical cyclization, and provides a secure strategy for a future synthesis of pentofuranoses and nucleoside analogues.

Indicateurs

1 Consultations de la notice

Détails

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