Abstract
N-Arylsulfonamide-based adenosine analogues were previously shown to be potent inhibitors of SARS-CoV-2 RNA cap guanine N7-methyltransferase nsp14. Here, we synthesized three series of N-arylsulfonamide acyclic analogues of adenosine as bisubstrates of nsp14. Most of these acyclic compounds were barely active at 50 μM against this cap N7-methyltransferase.