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Synthesis of Pyrimidine-Containing Nucleoside β-(R/S)-Hydroxyphosphonate Analogues
Article de revue   Open Access   Avec comité de lecture

Synthesis of Pyrimidine-Containing Nucleoside β-(R/S)-Hydroxyphosphonate Analogues

Maïa Meurillon, Laurent Chaloin, Christian Perigaud et Suzanne Peyrottes
European Journal of Organic Chemistry, (20-21), pp.3794-3802
2011
DOI: https://doi.org/10.1002/ejoc.201100219

Résumé

Nucleotides Reduction Molecular modeling Phosphonates Ribonucleosides Nucleotides modèle moléculaire synthèse asymétrique aminoacide dérive nucléotide phosphonate pyrimidine ribonucléoside
A concise route to nucleoside β-hydroxyphosphonate analogues is described. The use of a nucleoside β-ketophosphonate as the key intermediate allowed both the (R) and (S) isomers of β-hydroxyphosphonate analogues in the pyrimidine series to be accessed. Such derivatives may be considered as stable mimics of 5

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