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Synthesis of 2',3'-cyclohexen bicyclic uridine analogues using ring closure metathesis
Journal article   Peer reviewed

Synthesis of 2',3'-cyclohexen bicyclic uridine analogues using ring closure metathesis

Jullien Drone, Maxim Egorov, Wilfried Hatton, Marie-Jo Bertrand, Christophe Len and Jacques Lebreton
SYNLETT, Vol.9, pp.1339-1342
01/06/2006

Abstract

antivirals nucleic acid analogues radical allylation ring-closure metathesis
The synthesis of two new 2¢,3¢-cyclohexen bicyclic uridine analogues is described. From 5¢-protected uridine two successive tin radical-mediated allylations at 2'-C and 3'-C position followed by ring-closure olefin metathesis on the diene intermediate using Grubbs' catalyst led to the formation of the six-membered ring.
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