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Synthesis, characterization and free radical scavenging properties of rosmarinic acid fatty esters
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Synthesis, characterization and free radical scavenging properties of rosmarinic acid fatty esters

Jérôme J. Lecomte, Luis Javier Lopez Giraldo, Mickaël Laguerre, Bruno Barea et Pierre P. Villeneuve
Journal of the American Oil Chemists' Society, Vol.87(6), pp.615-620
2010

Résumé

STATIONARY STATE DPPH RADICAL SCAVENGING PROPERTIES NMR AND MASS SPECTROMETRY CHARACTERIZATION SYNTHESES ROSMARINIC ACID FATTY ESTERS ETAT STATIONNAIRE ESTERS ACIDE ROSMARINIQUE spectrométrie de masse synthèse organique
The hydrophobation of rosmarinic acid with saturated aliphatic primary alcohols of various chain lengths (methanol to eicosanol) was achieved via an acid-catalyzed esterification in the presence of a highly acidic sulfonic resin. The resulting alkyl rosmarinates were isolated, characterized and their global free radical scavenging activity was determined by the 2,2-diphenyl-1-picrylhydrazyl method in the stationary state. Only the dodecyl ester showed a stronger activity than rosmarinic acid

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