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Synthesis and purification of oligonucleotides containing sulfur substituted nucleobases : 4- thiouracil, 4-thiothymine and 6-mercaptopurine
Article de revue   Avec comité de lecture

Synthesis and purification of oligonucleotides containing sulfur substituted nucleobases : 4- thiouracil, 4-thiothymine and 6-mercaptopurine

Pascale Clivio, Jean Louis Fourrey, Jeannette Gasche, Annie Audic, Alain Favre, Catherine Perrin et Anne Woisard
Tetrahedron letters, Vol.33(1), pp.65-68
1992
DOI: https://doi.org/10.1016/S0040-4039(00)77674-X

Résumé

4-thiouracil 6-mercaptopurine gel eletrophoresis oligonucleotide
A procedure to obtain oligodeoxynucleotides containing sulfur substituted nucleobases is described. A procedure to obtain oligodeoxynucleotides containing sulfur modified nucleobases by standard application of the current phosphoramidite methodology is described as well as their purification technique.

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