Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

Stéphanie Ortial; Severine Denoyelle; Sharon Wein; Olivier Berger; Thierry Durand; Roger Escale; Alain Pellet; Henri Vial; Yen Vo-Hoang

doi:10.1002/cmdc.200900427

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Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

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Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

Stéphanie Ortial, Severine Denoyelle, Sharon Wein, Olivier Berger, Thierry Durand, Roger Escale, Alain Pellet, Henri Vial and Yen Vo-Hoang

ChemMedChem, Vol.5(1), pp.52-55

2010

DOI: https://doi.org/10.1002/cmdc.200900427

Abstract

biological activity

hybrid bis-cations

malaria

phospholipid metabolism

structure activity relationships

A new series of hybrid bis-cations has been synthesized as potent antimalarial agents. These drugs share two different cationic heads derived from bis-thiazolium and bis-amidine salts. Structure-activity relationships has been defined and pointed out that the linker plays a prior role for antimalarial activity leading to compounds with significant oral activity.

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Title: Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs
Creators - without role: Stéphanie Ortial - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Severine Denoyelle - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Sharon Wein - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
Olivier Berger - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Thierry Durand - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Roger Escale - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Alain Pellet - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
Henri Vial - Université de Montpellier, Laboratory of Pathogens and Host Immunity - LPHI
Yen Vo-Hoang - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Publication Details: ChemMedChem, Vol.5(1), pp.52-55
Identifiers: 9946562309311
Academic Unit: Laboratory of Pathogens and Host Immunity - LPHI; Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-00448020