Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine

Vladimir Bezuglov; Mikhail Bobrov; Natalia Gretskaya; Alla Gonchar; Galina Zinchenko; Dominique Melck; Tiziana Bisogno; Vincenzo Di Marzo; Dmitry Kuklev; Jean-Claude Rossi; Jean-Pierre Vidal; Thierry Durand

doi:10.1016/S0960-894X(00)00689-2

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Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine

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Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine

Vladimir Bezuglov, Mikhail Bobrov, Natalia Gretskaya, Alla Gonchar, Galina Zinchenko, Dominique Melck, Tiziana Bisogno, Vincenzo Di Marzo, Dmitry Kuklev, Jean-Claude Rossi, …

Bioorganic & medicinal chemistry letters, Vol.11(4), pp.447-449

26/02/2001

DOI: https://doi.org/10.1016/S0960-894X(00)00689-2

PMID: 11229744

Résumé

New amides of different fatty acids from the C18, C20, and C22 series with dopamine were synthesized. Pharmacological characterization in binding assays with rat brain membrane preparations and in the ‘tetrad’ of cannabinoid behavioral tests showed that, for these compounds, cannabinoid-like activity was dependent on the fatty acid moiety. Our data demonstrate that polyenoic fatty acid amides with dopamine comprise a new family of synthetic cannabimimetics. Amides of fatty acids from C18, C20, and C22 series with dopamine have been synthesized and theircannabimimetic properties were demonstrated.

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Titre: Synthesis and biological evaluation of novel amides of polyunsaturated fatty acids with dopamine
Créateurs - sans rôle: Vladimir Bezuglov - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Mikhail Bobrov - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Natalia Gretskaya - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Alla Gonchar - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Galina Zinchenko - Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya str., 117437 Moscow, Russia
Dominique Melck - Istituto per la Chimica di Molecole di Interesse Biologico, C.N.R., Via Toiano 6, 80072, Arco Felice, Napoli, Italy
Tiziana Bisogno - Istituto per la Chimica di Molecole di Interesse Biologico, C.N.R., Via Toiano 6, 80072, Arco Felice, Napoli, Italy
Vincenzo Di Marzo - Istituto per la Chimica di Molecole di Interesse Biologico, C.N.R., Via Toiano 6, 80072, Arco Felice, Napoli, Italy
Dmitry Kuklev - Pacific Research Institute of Fisheries & Oceanography (TINRO), 4 Shevchenko str., 690600 Vladivostok, Russia
Jean-Claude Rossi - Laboratoire de Chimie Biomoléculaire et Intéractions Biologiques associé au C.N.R.S., Université Montpellier I, Faculté de Pharmacie, 15 Av. Ch. Flahault, F-34060 Montpellier, France
Jean-Pierre Vidal - Laboratoire de Chimie Biomoléculaire et Intéractions Biologiques associé au C.N.R.S., Université Montpellier I, Faculté de Pharmacie, 15 Av. Ch. Flahault, F-34060 Montpellier, France
Thierry Durand - Laboratoire de Chimie
Détails de publication: Bioorganic & medicinal chemistry letters, Vol.11(4), pp.447-449
Éditeur: Elsevier Ltd
Nombre de pages: 3
Identifiants: 99138909909311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article