Résumé
2′-Deoxy-2′-
C
-trifluoromethyl-β-
d
-ribonucleoside derivatives bearing the five naturally occurring acid bases have been synthesized. All these derivatives were prepared by glycosylation reactions of purine and pyrimidine bases with a suitable peracylated 2-deoxy-2-
C
-trifluoromethyl sugar precursor to afford anomeric mixtures of protected nucleosides. After separation and deprotection, the resulting β-nucleoside analogues were tested for their activity against HIV, HBV and several RNA viruses. However, none of these compounds showed significant antiviral activity nor cytotoxicity.
2′-Deoxy-2′-
C
-trifluoromethyl-β-
d
-ribonucleosides have been synthesized. Unfortunately, none of these compounds show significant antiviral activity against HIV, HBV and several RNA viruses.