Logo image
Sign in
Back
Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.
Journal article   Peer reviewed

Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.

Mahama Ouattara, Sharon Wein, Michèle Calas, Yen Vo-Hoang, Henri Vial and Roger Escale
Bioorganic and Medicinal Chemistry Letters, Vol.17(3), pp.593-6
01/02/2007
DOI: https://doi.org/10.1016/j.bmcl.2006.11.013
PMID: 17123818

Abstract

Administration, Oral Alkanes Malaria Malaria, Falciparum Mice Plasmodium cynomolgi Plasmodium falciparum Amidines Animals Antimalarials Female Humans Hydroxylation Indicators and Reagents Injections, Intraperitoneal
Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N'-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.
url
Find in HALView

Metrics

1 Record Views

Details

Logo image