Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines

Christophe Mathé; Thierry Lioux; Gilles Gosselin

doi:10.1081/NCN-120021964

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Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines

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Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines

Christophe Mathé, Thierry Lioux et Gilles Gosselin

Nucleosides, nucleotides & nucleic acids, Vol.22(5-8), pp.605-609

01/10/2003

DOI: https://doi.org/10.1081/NCN-120021964

PMID: 14565237

Résumé

Azido-tetrazolo tautomerism

Nucleoside analogues

β -D-pentofuranonucleoside derivatives of 2-azidoadenine and 6-azidopurines have been synthesized. The azido-tetrazolo tautomerism observed on such nucleoside analogues has been studied. The compounds were tested for their activity against HIV and HBV but they did not show significant antiviral effect.

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Détails

Titre: Synthesis and Biological Evaluation of β-D-Pentofuranonucleoside Derivatives of 2-Azidoadenine and 6-Azidopurines
Créateurs - sans rôle: Christophe Mathé - Laboratoire de Chimie Organique
Thierry Lioux - Laboratoire de Chimie Organique Biomoléculaire de Synthèse , CNRS-Université Montpellier II
Gilles Gosselin - Laboratoire Coopératif Idenix , CNRS-Université Montpellier II
Détails de publication: Nucleosides, nucleotides & nucleic acids, Vol.22(5-8), pp.605-609
Éditeur: Taylor & Francis Group
Nombre de pages: 5
Identifiants: 99139000909311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article