Synthesis and Antiviral Evaluation of β-D- and β-L-Pentofuranonucleoside Derivatives Bearing 5-Trifluoromethylcytosine as the Base

Arnaud Marchand; Christophe Mathé; Gilles Gosselin

doi:10.1081/NCN-120022672

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Synthesis and Antiviral Evaluation of β-D- and β-L-Pentofuranonucleoside Derivatives Bearing 5-Trifluoromethylcytosine as the Base

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Synthesis and Antiviral Evaluation of β-D- and β-L-Pentofuranonucleoside Derivatives Bearing 5-Trifluoromethylcytosine as the Base

Arnaud Marchand, Christophe Mathé et Gilles Gosselin

Nucleosides, nucleotides & nucleic acids, Vol.22(5-8), pp.861-863

01/10/2003

DOI: https://doi.org/10.1081/NCN-120022672

PMID: 14565297

Résumé

5-Trifluoromethylcytosine

Antiviral evaluations

D- and

β-L-Nucleoside analogues

β -D- and β -L-pentofuranonucleoside derivatives bearing 5-trifluoromethylcytosine as the base have been synthesized. The compounds were tested for their activity against HIV and HBV, but they did not show significant antiviral effect.

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Détails

Titre: Synthesis and Antiviral Evaluation of β-D- and β-L-Pentofuranonucleoside Derivatives Bearing 5-Trifluoromethylcytosine as the Base
Créateurs - sans rôle: Arnaud Marchand - Laboratoire de Chimie Organique Biomoléculaire de Synthèse
Christophe Mathé - Université de Montpellier
Gilles Gosselin - Laboratoire Coopératif Idenix, CNRS , Université Montpellier II
Détails de publication: Nucleosides, nucleotides & nucleic acids, Vol.22(5-8), pp.861-863
Éditeur: Taylor & Francis Group
Nombre de pages: 3
Identifiants: 99139003609311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article