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Synthesis, Stability, and Biological Evaluation of 1,3-Dihydrobenzo[c]furan Analogue of d4T and Its SATE Pronucleotide
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Synthesis, Stability, and Biological Evaluation of 1,3-Dihydrobenzo[c]furan Analogue of d4T and Its SATE Pronucleotide

Christophe Len, Abdelmajid Selouane, Denis Postel, Pierre Villa, Anne-Marie Aubertin, David Egron, Gilles Gosselin et Christian Périgaud
Nucleosides, nucleotides & nucleic acids, Vol.22(5-8), pp.943-945
01/10/2003
DOI: https://doi.org/10.1081/NCN-120022691
PMID: 14565317

Résumé

1,3-Dihydrobenzo[c]furane d4T SATE pronucleotide
The anti-HIV activity and stability studies of 1,3-dihydrobenzo[c]furan analogue of d4T are reported. The corresponding mononucleoside phosphotriester derivative bearing a S-pivaloyl-2-thioethyl (tBuSATE) group, as biolabile phosphate protection, is also studied.

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