Logo image
Se connecter
Retour
Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents
Article de revue   Avec comité de lecture

Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

Ana Gil, Adriana Pabon, Silvia Galiano, Asuncion Burguete, Silvia Perez-Silanes, Eric Deharo, Antonio Monge et Ignacio Aldana
Molecules (Basel, Switzerland), Vol.19(2), pp.2166-2180
18/02/2014
DOI: https://doi.org/10.3390/molecules19022166
PMID: 24552985

Résumé

Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Life Sciences & Biomedicine Physical Sciences Science & Technology
We report the synthesis and antimalarial activities of eighteen quinoxaline and quinoxaline 1,4-di-N-oxide derivatives, eight of which are completely novel. Compounds 1a and 2a were the most active against Plasmodium falciparum strains. Structure-activity relationships demonstrated the importance of an enone moiety linked to the quinoxaline ring.

Indicateurs

1 Consultations de la notice

Détails

Logo image