Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives

Zohra Benfodda; Vanessa Fritz; Corinne Henriquet; Caterina Fattorusso; Gerardo Cebrian Cebrian-Torrejon; Marco Persico; Antonio Di Dato; Marialuisa Menna; Hubert Blancou; Lluis Fajas

doi:10.4172/2161-0444.1000466

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Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives

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Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives

Zohra Benfodda, Vanessa Fritz, Corinne Henriquet, Caterina Fattorusso, Gerardo Cebrian Cebrian-Torrejon, Marco Persico, Antonio Di Dato, Marialuisa Menna, Hubert Blancou and Lluis Fajas

Medicinal Chemistry, Vol.7(9), pp.257-267

2017

DOI: https://doi.org/10.4172/2161-0444.1000466

Abstract

1-acyl-4-sulfonylpiperazines

Prostate cancer

Antiproliferative activity

Molecular modelling

SAR

A series of 1-acyl-4-sulfonylpiperazine derivatives has been prepared. The antiproliferative effect of these compounds was evaluated in vitro against human prostate cancer cell line C4-2, several among them exhibited interesting growth inhibitory against this particular cell line. Finally, a molecular modeling study was employed to analyze the structure/activity relationships (SAR) of these novel compounds..

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Title: Synthesis, Anticancer Activity and Computational SAR Analysis of Acylsulfonylpiperazines Derivatives
Creators - without role: Zohra Benfodda - Université de Nîmes
Vanessa Fritz - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Corinne Henriquet - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Caterina Fattorusso - University of Naples Federico II
Gerardo Cebrian Cebrian-Torrejon - Université de Nîmes
Marco Persico - University of Naples Federico II
Antonio Di Dato - University of Naples Federico II
Marialuisa Menna - University of Naples Federico II
Hubert Blancou - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Lluis Fajas - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
Publication Details: Medicinal Chemistry, Vol.7(9), pp.257-267
Identifiers: 9939429509311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM; Institut des Biomolécules Max Mousseron - IBMM
Language: English
Resource Type: Journal article
Local Fields: hal-01662364