Résumé
Nanoscale objects with highly symmetrical cage-like polyhedral shapes, often with icosahedral symmetry, have recently been assembled using DNA 1-3 , RNA 4 , and proteins 5,6 for biomedical applications. These achievements relied on advances in the development of programmable self-assembling biomaterials 7-10 , as well as rapidly developing single-particle three-dimensional (3D) reconstruction techniques of cryo electron microscopy (cryo-EM) images that provide high-resolution structural characterization of biological complexes 11-13. In contrast, such single-particle 3D