Sugar modified oligonucleotides: Synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4′-thio-β-d-ribofuranosyl)-thymine

Laurent Bellon; François Morvan; Jean-Louis Barascut; Jean-Louis Imbach

doi:10.1016/0006-291X(92)90660-D

Retour

Sugar modified oligonucleotides: Synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4′-thio-β-d-ribofuranosyl)-thymine

Article de revue

Avec comité de lecture

Sugar modified oligonucleotides: Synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4′-thio-β-d-ribofuranosyl)-thymine

Laurent Bellon, François Morvan, Jean-Louis Barascut et Jean-Louis Imbach

Biochemical and biophysical research communications, Vol.184(2), pp.797-803

30/04/1992

DOI: https://doi.org/10.1016/0006-291X(92)90660-D

PMID: 1315535

Résumé

XdT 12 and dT 5XdT 6, where X is 1-(4′-thio-β-d-ribofuranosyl)-thymine, were synthesized. The first oligonucleotide presents a better stability against calf spleen phosphodiesterase than natural dT 12. The second one hybridizes with complementary sequence. However the X:A base pairing stability is lower than natural T:A one.

Indicateurs

1 Consultations de la notice

Détails

Titre: Sugar modified oligonucleotides: Synthesis, nuclease resistance and base pairing of oligodeoxynucleotides containing 1-(4′-thio-β-d-ribofuranosyl)-thymine
Créateurs - sans rôle: Laurent Bellon
François Morvan
Jean-Louis Barascut
Jean-Louis Imbach
Détails de publication: Biochemical and biophysical research communications, Vol.184(2), pp.797-803
Éditeur: Elsevier Inc
Nombre de pages: 7
Identifiants: 99138900209311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article