Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of α- and β-L-octathymidylates

François Morvan; Corinne Génu; Bernard Rayner; Gilles Gosselin; Jean-Louis Imbach

doi:10.1016/0006-291X(90)90706-S

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Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of α- and β-L-octathymidylates

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Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of α- and β-L-octathymidylates

François Morvan, Corinne Génu, Bernard Rayner, Gilles Gosselin et Jean-Louis Imbach

Biochemical and biophysical research communications, Vol.172(2), pp.537-543

30/10/1990

DOI: https://doi.org/10.1016/0006-291X(90)90706-S

PMID: 2173569

Résumé

Two unatural L-oligodeoxyribonucleotides, namely α- and β-L-dT 8pO(CH 2) 3OH, have been synthesized. These oligomers are resistant towards nuclease degradation. They do not show any UV detectable base pairing with β-D-dA 8 and poly rA.

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Titre: Sugar modified oligonucleotides. III (1). Synthesis, nuclease resistance and base pairing properties of α- and β-L-octathymidylates
Créateurs - sans rôle: François Morvan
Corinne Génu
Bernard Rayner
Gilles Gosselin
Jean-Louis Imbach
Détails de publication: Biochemical and biophysical research communications, Vol.172(2), pp.537-543
Éditeur: Elsevier Inc
Nombre de pages: 7
Identifiants: 99138882909311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article