Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

Francoise Debart; Bernard Rayner; Jeon-Louis Imbach

doi:10.1016/S0040-4039(00)94436-8

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Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

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Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents

Francoise Debart, Bernard Rayner et Jeon-Louis Imbach

Tetrahedron letters, Vol.31(25), pp.3537-3540

01/1990

DOI: https://doi.org/10.1016/S0040-4039(00)94436-8

Résumé

Chemical Sciences

α-anomeric uridylates, α-rU6 and α-rU12, have been synthesized for the first time. These non natural α-oligoribonucleotides strongly resist to enzymatic degradation and bind to complementary RNA strands.

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Détails

Titre: Sugar modified oligonucleotides : II. Solid phase synthesis of nuclease resistant α-anomeric uridylates as potential antisense agents
Créateurs - sans rôle: Francoise Debart - LCBO-Laboratoire de Chimie Bio-organique
Bernard Rayner - Laboratoire de Chimie
Jeon-Louis Imbach - LCBO-Laboratoire de Chimie Bio-organique
Détails de publication: Tetrahedron letters, Vol.31(25), pp.3537-3540
Éditeur: Elsevier
Nombre de pages: 4
Identifiants: 99138720309311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article