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Successful treatment of a Streptococcus pneumoniae- associated haemolytic uraemic syndrome by eculizumab
Journal article   Open access   Peer reviewed

Successful treatment of a Streptococcus pneumoniae- associated haemolytic uraemic syndrome by eculizumab

Guillaume Jeantet, Vincent Pernin, Vincent Brunot, Arnaud Roccabianca, Anouk Macombe, Ilan Szwarc, Kada Klouche, Chantal Loirat, Georges Mourad, Veronique Fremeaux-Bacchi, …
Clinical Kidney Journal, Vol.12(1), pp.106-109
2019
DOI: https://doi.org/10.1093/ckj/sfy019
PMID: 30746136

Abstract

thrombotic microangiopathy Streptococcus pneumoniae complement eculizumab haemolytic uraemic syndrome
Haemolytic uraemic syndrome (HUS) is a rare complication of invasive infection by Streptococcus pneumoniae (SP-HUS), especially in adults. Here we report an unusual case of a 53-year-old man presenting SP-HUS with severe multivisceral involvement. After failure of supportive care and plasma exchanges, eculizumab (anti-C5 antibody) resulted in a favourable outcome.
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