Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Célina Ducroux; Laurent Derex; Mikaïl Nourredine; Julie Haesebaert; Marielle Buisson; Walid Alesefir; William Boisseau; Nicole Daneault; Yan Deschaintre; Jose Danilo B. Diestro; Omer Eker; Johanna Eneling; Laura C. Gioia; Daniella Iancu; Grégory Jacquin; Céline Odier; Christian Stapf; Jean Raymond; Daniel Roy; Alain Weill; Bertrand Lapergue; Alexandre Y. Poppe; Michel Piotin; Raphael Blanc; Hocine Redjem Simon Escalard; Jean-Philippe Desilles; François Delvoye; Stanislas Smajda; Benjamin Maier; Solène Hebert; Mikael Mazighi; Mikael Obadia; Candice Sabben; Pierre Seners; Igor Raynouard; Ovide Corabianu; Thomas de Broucker; Eric Manchon; Guillaume Taylor; Malek Ben Maacha; Laurie-Anne Thion; Augustin Lecler; Julien Savatovsky; Adrien Wang; Serge Evrard; Maya Tchikviladze; Nadia Ajili; David Weisenburger-Lile; Lucas Gorza; Géraldine Buard; Oguzhan Coskun; Arturo Consoli; Federico Di Maria; Georges Rodesh; Sergio Zimatore; Morgan Leguen; Julie Gratieux; Fernando Pico; Haja Rakotoharinandrasana; Philippe Tassan; Roxanna Poll; Sylvie Marinier; Norbert Nighoghossian; Roberto Riva; Francis Turjman; Tae-Hee Cho; Laura Mechtouff; Anne Claire Lukaszewicz; Frédéric Philippeau; Serkan Cakmak; Karine Blanc-Lasserre; Anne-Evelyne Vallet; Gaultier Marnat; Florent Gariel; Xavier Barreau; Jérôme Berge; Patrice Menegon; Igor Sibon; Ludovic Lucas; Stéphane Olindo; Pauline Renou; Sharmila Sagnier; Mathilde Poli; Sabrina Debruxelles; François Rouanet; Thomas Tourdias; Jean-Sebastien Liegey; Pierre Briau; Nicolas Pangon; Romain Bourcier; Lili Detraz; Benjamin Daumas-Duport; Pierre-Louis Alexandre; Monica Roy; Cédric Lenoble; Hubert Desal; Benoît Guillon; Solène de Gaalon; Cécile Preterre; Benjamin Gory; Serge Bracard; René Anxionnat; Marc Braun; Anne-Laure Derelle; Romain Tonnelet; Liang Liao; François Zhu; Emmanuelle Schmitt; Sophie Planel; Sébastien Richard; Lisa Humbertjean; Gioia Mione; Jean-Christophe Lacour; Nolwenn Riou-Comte; Gérard Audibert; Marcela Voicu; Ionel Alb; Marie Reitter; Madalina Brezeanu; Agnès Masson; Adriana Tabarna; Iona Podar; Francisco Macian-montoro; Suzanna Saleme; Charbel Mounayer; Aymeric Rouchaud; Vincent Costalat; Caroline Arquizan; Cyril Dargazanli; Grégory Gascou; Pierre-Henri Lefèvre; Imad Derraz; Carlos Riquelme; Nicolas Gaillard; Isabelle Mourand; Lucas Corti; Federico Cagnazzo; Adrien ter Schiphorst; Eugene Francois; Stéphane Vannier; Jean-christophe Ferre; Helene Raoult; Thomas Ronziere; Maria Lassale; Christophe Paya; Jean-Yves Gauvrit; Clément Tracol; Sophie Langnier-Lemercier; Yves Samson; Charlotte Rosso; Anne Leger; Sandrine Deltour; Frederic Clarencon; Eimad Shotar; Laurent Spelle; Christian Denier; Olivier Chassin; Vanessa Chalumeau; Jildaz Caroff; Laura Venditti; Olivier Naggara; Wagih Ben Hassen; Grégoire Boulouis; Christine Rodriguez-Régent; Denis Trystram; Basile Kerleroux; Guillaume Turc; Valérie Domigo; Catherine Lamy; Julia Birchenall; Clothilde Isabel; François Lun; Alain Viguier; Christophe Cognard; Anne Christine Januel; Jean-Marc Olivot; Nicolas Raposo; Fabrice Bonneville; Jean François Albucher; Lionel Calviere; Jean Darcourt; Philippe Tall; Guillaume Bellanger; Louis Fontaine; Emmanuel Touze; Charlotte Barbier; Romain Schneckenburger; Marion Boulanger; Julien Cogez; Sophie Guettier; Serge Timsit; Jean-christophe Gentric; Julien Ognard; Francois Mathias Merrien; Ozlem Ozkul Wermester; Evelyne Massardier; Chrysanthi Papagiannaki; Frédéric Bourdain; Patricia Bernady; Laurent Lagoarde-Segot; Hélène Cailliez; Louis Veunac; David Higue; Valérie Wolff; Raoul Pop; Rémi Beaujeux; Mihoc Dan-Sorin; Monica Manisor; Anthony Le Bras; Sarah Evain; Arnaud Le Guen; Sebastian Richter; Regis Hubrecht; Stéphanie Demasles; Bruno Barroso; Denis Sablot; Geoffroy Farouil; Maxime Tardieu; Philippe Smadja; Sabine Aptel; Ian Seiler; ETIS (Endovascular Treatment in Ischemic Stroke) Investigators

doi:10.1016/j.neurad.2022.03.006

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Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

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Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Célina Ducroux, Laurent Derex, Mikaïl Nourredine, Julie Haesebaert, Marielle Buisson, Walid Alesefir, William Boisseau, Nicole Daneault, Yan Deschaintre, Jose Danilo B. Diestro, …

Journal of neuroradiology, Vol.50(1), pp.59-64

01/02/2023

DOI: https://doi.org/10.1016/j.neurad.2022.03.006

PMID: 35341899

Résumé

Interventional-thrombolysis

Stroke

Patients with pre-stroke disability, defined as a modified Rankin Scale (mRS) ≥3, were excluded from most trials of endovascular thrombectomy (EVT) for acute stroke. We sought to evaluate the prognostic factors associated with favorable outcome in stroke patients with known disability undergoing EVT, and the impact of successful reperfusion. Consecutive acute stroke patients with pre-stroke disability, undergoing EVT, were retrospectively collected between 2016 to 2019 from a Canadian cohort and a multicenter French cohort (Endovascular Treatment in Ischemic Stroke registry-ETIS). Favorable outcome was defined as an mRS equal to pre-stroke mRS. Patients achieving successful reperfusion (defined as a modified Thrombolysis in Cerebral Infarction score of 2b/3) were compared with patients without successful reperfusion to determine if successful EVT was associated with better functional outcomes. Among 6220 patients treated with EVT, 280 (4.5%) patients with a pre-stroke mRS ≥3 were included. Sixty-one patients (21.8%) had a favorable outcome and 146 (52.1%) died at 3 months. Patients with successful reperfusion had a higher proportion of favorable 90-day mRS (27.6% versus 19.6%, p = 0.025) and a lower mortality (48.3% versus 69.6%, p = 0.008) than patients without successful reperfusion. After adjusting for baseline prognostic factors, successful reperfusion defined by TICI ≥2b was associated with favorable functional outcome (OR 3.16 CI95% [1.11–11.5]; p 0.048). In patients with pre-stroke disability, successful reperfusion is associated with a greater proportion of favorable outcome and lower mortality. [Display omitted] •Stroke patients with pre-stroke mRS ≥3 treated with EVT have a high 90-day mortality rate.•Reperfusion in disabled patients is associated with preservation of function and lower mortality.•EVT should not be systematically withheld from patients with pre-stroke disability.

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Titre: Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study
Créateurs - sans rôle: Célina Ducroux - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Laurent Derex - Hospices Civils de Lyon
Mikaïl Nourredine - Department of Research and Epidemiology, Pôle de Santé Publique, Hospices Civils de Lyon, Lyon, France
Julie Haesebaert - Department of Research and Epidemiology, Pôle de Santé Publique, Hospices Civils de Lyon, Lyon, France
Marielle Buisson - Clinical Investigation Center, INSERM 1407, Louis Pradel Hospital, Hospices Civils de Lyon, Lyon, France
Walid Alesefir - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
William Boisseau - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Nicole Daneault - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Yan Deschaintre - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Jose Danilo B. Diestro - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Omer Eker - Hospices Civils de Lyon
Johanna Eneling - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Laura C. Gioia - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Daniella Iancu - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Grégory Jacquin - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Céline Odier - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Christian Stapf - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Jean Raymond - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Daniel Roy - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Alain Weill - Department of Radiology, Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada
Bertrand Lapergue - Department of Neurology, Foch Hospital, Suresnes, France
Alexandre Y. Poppe - Department of Neurosciences, Faculté de médecine, Université de Montréal, Montréal, QC, Canada
Michel Piotin
Raphael Blanc
Hocine Redjem Simon Escalard
Jean-Philippe Desilles
François Delvoye
Stanislas Smajda
Benjamin Maier
Solène Hebert
Mikael Mazighi
Mikael Obadia
Candice Sabben
Pierre Seners
Igor Raynouard
Ovide Corabianu
Thomas de Broucker
Eric Manchon
Guillaume Taylor
Malek Ben Maacha
Laurie-Anne Thion
Augustin Lecler
Julien Savatovsky
Adrien Wang
Serge Evrard
Maya Tchikviladze
Nadia Ajili
Bertrand Lapergue
David Weisenburger-Lile
Lucas Gorza
Géraldine Buard
Oguzhan Coskun
Arturo Consoli
Federico Di Maria
Georges Rodesh
Sergio Zimatore
Morgan Leguen
Julie Gratieux
Fernando Pico
Haja Rakotoharinandrasana
Philippe Tassan
Roxanna Poll
Sylvie Marinier
Norbert Nighoghossian
Roberto Riva
Omer Eker
Francis Turjman
Laurent Derex
Tae-Hee Cho
Laura Mechtouff
Anne Claire Lukaszewicz
Frédéric Philippeau
Serkan Cakmak
Karine Blanc-Lasserre
Anne-Evelyne Vallet
Gaultier Marnat
Florent Gariel
Xavier Barreau
Jérôme Berge
Patrice Menegon
Igor Sibon
Ludovic Lucas
Stéphane Olindo
Pauline Renou
Sharmila Sagnier
Mathilde Poli
Sabrina Debruxelles
François Rouanet
Thomas Tourdias
Jean-Sebastien Liegey
Pierre Briau
Nicolas Pangon
Romain Bourcier
Lili Detraz
Benjamin Daumas-Duport
Pierre-Louis Alexandre
Monica Roy
Cédric Lenoble
Hubert Desal
Benoît Guillon
Solène de Gaalon
Cécile Preterre
Benjamin Gory
Serge Bracard
René Anxionnat
Marc Braun
Anne-Laure Derelle
Romain Tonnelet
Liang Liao
François Zhu
Emmanuelle Schmitt
Sophie Planel
Sébastien Richard
Lisa Humbertjean
Gioia Mione
Jean-Christophe Lacour
Nolwenn Riou-Comte
Gérard Audibert
Marcela Voicu
Ionel Alb
Marie Reitter
Madalina Brezeanu
Agnès Masson
Adriana Tabarna
Iona Podar
Francisco Macian-montoro
Suzanna Saleme
Charbel Mounayer
Aymeric Rouchaud
Vincent Costalat
Caroline Arquizan
Cyril Dargazanli
Grégory Gascou
Pierre-Henri Lefèvre
Imad Derraz
Carlos Riquelme
Nicolas Gaillard
Isabelle Mourand
Lucas Corti
Federico Cagnazzo
Adrien ter Schiphorst
Eugene Francois
Stéphane Vannier
Jean-christophe Ferre
Helene Raoult
Thomas Ronziere
Maria Lassale
Christophe Paya
Jean-Yves Gauvrit
Clément Tracol
Sophie Langnier-Lemercier
Yves Samson
Charlotte Rosso
Anne Leger
Sandrine Deltour
Frederic Clarencon
Eimad Shotar
Laurent Spelle
Christian Denier
Olivier Chassin
Vanessa Chalumeau
Jildaz Caroff
Laura Venditti
Olivier Naggara
Wagih Ben Hassen
Grégoire Boulouis
Christine Rodriguez-Régent
Denis Trystram
Basile Kerleroux
Guillaume Turc
Valérie Domigo
Catherine Lamy
Julia Birchenall
Clothilde Isabel
François Lun
Alain Viguier
Christophe Cognard
Anne Christine Januel
Jean-Marc Olivot
Nicolas Raposo
Fabrice Bonneville
Jean François Albucher
Lionel Calviere
Jean Darcourt
Philippe Tall
Guillaume Bellanger
Louis Fontaine
Emmanuel Touze
Charlotte Barbier
Romain Schneckenburger
Marion Boulanger
Julien Cogez
Sophie Guettier
Serge Timsit
Jean-christophe Gentric
Julien Ognard
Francois Mathias Merrien
Ozlem Ozkul Wermester
Evelyne Massardier
Chrysanthi Papagiannaki
Frédéric Bourdain
Patricia Bernady
Laurent Lagoarde-Segot
Hélène Cailliez
Louis Veunac
David Higue
Valérie Wolff
Raoul Pop
Rémi Beaujeux
Mihoc Dan-Sorin
Monica Manisor
Anthony Le Bras
Sarah Evain
Arnaud Le Guen
Sebastian Richter
Regis Hubrecht
Stéphanie Demasles
Bruno Barroso
Denis Sablot
Geoffroy Farouil
Maxime Tardieu
Philippe Smadja
Sabine Aptel
Ian Seiler
ETIS (Endovascular Treatment in Ischemic Stroke) Investigators
Détails de publication: Journal of neuroradiology, Vol.50(1), pp.59-64
Éditeur: Elsevier Masson SAS
Nombre de pages: 6
Identifiants: 99163083809311
Unité académique: Institut de Génomique Fonctionnelle - IGF; Recherche hors université
Langue: English
Type de ressource: Journal article