Successful Treatment of Trypanosoma cruzi Encephalitis in a Patient with Hemophilia and AIDS

Aldo Solari; Hernan Saavedra; Cecilia Sepúlveda; David Oddó; Guillermo Acuña; Jaime Labarca; Sergio Muñoz; Gérard Cuny; Cecille Brengues; Francisco Veas; Ralph T. Bryan

doi:10.1093/clind/16.2.255

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Successful Treatment of Trypanosoma cruzi Encephalitis in a Patient with Hemophilia and AIDS

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Successful Treatment of Trypanosoma cruzi Encephalitis in a Patient with Hemophilia and AIDS

Aldo Solari, Hernan Saavedra, Cecilia Sepúlveda, David Oddó, Guillermo Acuña, Jaime Labarca, Sergio Muñoz, Gérard Cuny, Cecille Brengues, Francisco Veas, …

Clinical infectious diseases, Vol.16(2), pp.255-259

01/02/1993

DOI: https://doi.org/10.1093/clind/16.2.255

PMID: 8382964

Résumé

Although the frequency of infection with the human immunodeficiency virus (HIV) is increasing dramatically in areas where Trypanosoma cruzi is endemic, trypanosomiasis has been rarely reported in persons with HIV infection or AIDS. Persons with hemophilia who receive multiple blood product transfusions from blood banks with little or no screening for infectious agents are at particularly high risk for infections with both HIV and T. cruzi. We describe the case of a person with hemophilia who was infected by blood transfusion with HIV and T. cruzi and in whom a multifocal, necrotic trypanosomal encephalitis was demonstrated by brain biopsy and electron microscopy. Treatment with benznidazole followed by that with itraconazole and fluconazole was associated with significant clinical and radiographic improvement.

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Titre: Successful Treatment of Trypanosoma cruzi Encephalitis in a Patient with Hemophilia and AIDS
Créateurs - sans rôle: Aldo Solari - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Hernan Saavedra - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Cecilia Sepúlveda - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
David Oddó - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Guillermo Acuña - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Jaime Labarca - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Sergio Muñoz - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Gérard Cuny - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Cecille Brengues - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Francisco Veas - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Ralph T. Bryan - Departamento de Bioquímica and Departamento de Farmacología, Facultad de Medicina, and the Laboratorio de Immunología, Departamento de Medicina, Hospital Clínico, Universidad de Chile, Santiago, ORSTOM, Montpellier, Atlanta, Georgia, Chile, France
Détails de publication: Clinical infectious diseases, Vol.16(2), pp.255-259
Éditeur: The University of Chicago Press
Nombre de pages: 5
Identifiants: 99159213009311
Unité académique: Hydrosciences Montpellier - HSM
Langue: English
Type de ressource: Journal article