Studies Toward the Synthesis of Inhibitors of Mycobacterium tuberculosis Cell-Wall Biosynthesis: The Assembly of Triazole-Linked 1,6-alpha-D-Oligomannosides via Click CuAAC

Mauro Lo Conte; Angela Chambery; Alberto Marra; Alessandro Dondoni

doi:10.1055/s-0029-1217751

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Studies Toward the Synthesis of Inhibitors of Mycobacterium tuberculosis Cell-Wall Biosynthesis: The Assembly of Triazole-Linked 1,6-alpha-D-Oligomannosides via Click CuAAC

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Studies Toward the Synthesis of Inhibitors of Mycobacterium tuberculosis Cell-Wall Biosynthesis: The Assembly of Triazole-Linked 1,6-alpha-D-Oligomannosides via Click CuAAC

Mauro Lo Conte, Angela Chambery, Alberto Marra et Alessandro Dondoni

Synlett, Vol.2009(16), pp.2679-2681

01/10/2009

DOI: https://doi.org/10.1055/s-0029-1217751

Résumé

Chemistry

Chemistry, Organic

Physical Sciences

Science & Technology

A versatile synthesis of 1,6-alpha-D-oligomannosides featuring the 1,4-disubstituted triazole ring as interglycosidic tether is presented via iterative copper(I)-catalyzed azide-alkyne cycloaddition. Free hydroxy hexamannoside and decamannoside featuring a capping 6-deoxymannose fragment have been prepared and characterized.

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Titre: Studies Toward the Synthesis of Inhibitors of Mycobacterium tuberculosis Cell-Wall Biosynthesis: The Assembly of Triazole-Linked 1,6-alpha-D-Oligomannosides via Click CuAAC
Créateurs - sans rôle: Mauro Lo Conte - Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy
Angela Chambery - Univ Naples 2, Dipartimento Sci Vita, I-81100 Caserta, Italy
Alberto Marra - Univ Ferrara, Dipartmento Chim, Chim Organ Lab, I-44100 Ferrara, Italy
Alessandro Dondoni - University of Ferrara
Détails de publication: Synlett, Vol.2009(16), pp.2679-2681
Éditeur: Thieme Medical Publishers
Nombre de pages: 3
Identifiants: 99163058109311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article