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Strategies for cancer gene therapy using adenoviral vectors
Article de revue   Avec comité de lecture

Strategies for cancer gene therapy using adenoviral vectors

V Descamps, M T Duffour, M C Mathieu, N Fernandez, L Cordier, M A Abina, E Kremer, M Perricaudet et H Haddada
Journal of molecular medicine (Berlin, Germany), Vol.74(4), pp.183-189
01/04/1996
PMID: 8740649

Résumé

Adenoviridae - genetics Animals Clinical Trials as Topic Feasibility Studies Genetic Therapy - methods Genetic Vectors Humans Immunotherapy - methods Interleukin-2 - genetics Interleukin-2 - therapeutic use Mice Neoplasms - therapy
Modification of tumor cells using gene transfer either to enhance host immunity or to act directly on tumor cells is being intensively studied in animal models. Remarkable results have yielded to approved clinical protocols in the treatment of cancer patients using this approach. Several methods of gene delivery have been developed. This article is particularly devoted to the interest of the use of adenoviral vectors in the different strategies of cancer gene therapy.

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