Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors

Hanane Elayadi; Michael Smietana; Christophe Pannecouque; Pieter Leyssen; Johan Neyts; Jean-Jacques Vasseur; Hassan B. Lazrek

doi:10.1016/j.bmcl.2010.10.046

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Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors

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Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors

Hanane Elayadi, Michael Smietana, Christophe Pannecouque, Pieter Leyssen, Johan Neyts, Jean-Jacques Vasseur et Hassan B. Lazrek

Bioorganic and Medicinal Chemistry Letters, Vol.20, pp.7365-7368

2010

DOI: https://doi.org/10.1016/j.bmcl.2010.10.046

Résumé

antiviral

click chemistry

nucleotides analogues

HCV

Preparation of several triazoloacyclic nucleoside phosphonates is described. The key step of the synthesis involves a copper(I)-catalysed azide-alkyne 1,3-dipolar cycloaddition between azidoalkylphosphonates and propargylated nucleobases. The antiviral properties of these new analogues have been evaluated and revealed interesting potencies.

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Titre: Straightforward synthesis of triazoloacylonucleotide phosphonates as potential HCV inhibitors
Créateurs - sans rôle: Hanane Elayadi - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Michael Smietana - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Christophe Pannecouque - Rega Institute for Medical Research
Pieter Leyssen - KU Leuven
Johan Neyts - KU Leuven
Jean-Jacques Vasseur - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
Hassan B. Lazrek - Cadi Ayyad University
Détails de publication: Bioorganic and Medicinal Chemistry Letters, Vol.20, pp.7365-7368
Identifiants: 99153306909311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article
Champs locaux: hal-00616738