Résumé
The 3′,4′-seco nucleoside
5 as well as its derivatives lacking C(3′)
7 or 2′-deoxygenated
13, all of them retaining the carbon framework and chirality of guanosine, have been synthesized by ring opening of suitably protected 9-α-L-arabinopyranosylguanines.
The title compounds (X OH or H, Y CH
2OH or H) have been synthesized by ring opening of suitably protected 9-α-L-arabinopyranosylguanines. None of them showed significant activity against a variety of DNA and RNA viruses.