Abstract
Ring contraction of 2,5-diketopiperazines by TRAL-alkylation led us to the stereoselective synthesis of original pyrrolidine-2,4-diones, a novel series of promising molecules with moderate antiproliferative activity on breast cancer cells.
- Title
- Stereoselective ring contraction of 2,5-diketopiperazines : An innovative approach to the synthesis of promising bioactive 5-membered scaffolds
- Creators - without role
- Thilbault Coursindel - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMMAudrey Restouin - Centre de Recherche en Cancérologie de MarseilleGeorges Dewynter - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMMJean Martinez - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMMYves Collette - Institut Paoli-CalmettesIsabelle Parrot - Université de Montpellier, Institut des Biomolécules Max Mousseron - IBMM
- Publication Details
- Bioorganic Chemistry, Vol.38, pp.210-217
- Identifiers
- 9943328309311
- Academic Unit
- Institut des Biomolécules Max Mousseron - IBMM
- Language
- English
- Resource Type
- Journal article
- Local Fields
- hal-00599350