Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium faiciparum

Ahidjo Ayouba; Cyril Badaut; Anfumbom Kfutwah; Claude Cannou; Alexandre Juillerat; Stephane Gangnard; Charlotte Behr; Odile Mercereau-Puijalon; Graham A. Bentley; Francoise Barre-Sinoussi; Elisabeth Menu

doi:10.1097/QAD.0b013e3282f560ee

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Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium faiciparum

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Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium faiciparum

Ahidjo Ayouba, Cyril Badaut, Anfumbom Kfutwah, Claude Cannou, Alexandre Juillerat, Stephane Gangnard, Charlotte Behr, Odile Mercereau-Puijalon, Graham A. Bentley, Francoise Barre-Sinoussi, …

AIDS (London), Vol.22(6), pp.785-787

30/03/2008

DOI: https://doi.org/10.1097/QAD.0b013e3282f560ee

PMID: 18356610

Résumé

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Virology

Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding of a recombinant Plasmodium falciparum adhesin to chondroitin sulphate A proteoglycans increases HIV-1 replication in the human placental cell line BeWo, probably by a P. falciparum adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests that placental malaria could increase the risk of HIV-1 transmission in utero.

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Titre: Specific stimulation of HIV-1 replication in human placental trophoblasts by an antigen of Plasmodium faiciparum
Créateurs - sans rôle: Ahidjo Ayouba - Inst Pasteur, Unite Regulat Infect Retrovirales, F-75724 Paris 15, France
Cyril Badaut - Inst Pasteur, CNRS, URA 2185, Unite Immunol Struct, F-75724 Paris, France
Anfumbom Kfutwah - Ctr Pasteur Cameroun, Virol Lab, Yaounde, Cameroon
Claude Cannou - Inst Pasteur, Unite Regulat Infect Retrovirales, F-75724 Paris 15, France
Alexandre Juillerat - Inst Pasteur, CNRS, URA 2185, Unite Immunol Struct, F-75724 Paris, France
Stephane Gangnard - Inst Pasteur, CNRS, URA 2185, Unite Immunol Struct, F-75724 Paris, France
Charlotte Behr - Inst Pasteur, CNRS, URA 2581, Unite Immunol Mol Parasites, F-75724 Paris, France
Odile Mercereau-Puijalon - Inst Pasteur, CNRS, URA 2581, Unite Immunol Mol Parasites, F-75724 Paris, France
Graham A. Bentley - Inst Pasteur, CNRS, URA 2185, Unite Immunol Struct, F-75724 Paris, France
Francoise Barre-Sinoussi - Inst Pasteur, Unite Regulat Infect Retrovirales, F-75724 Paris 15, France
Elisabeth Menu - Inst Pasteur, Unite Regulat Infect Retrovirales, F-75724 Paris 15, France
Détails de publication: AIDS (London), Vol.22(6), pp.785-787
Éditeur: Lippincott Williams & Wilkins
Nombre de pages: 3
Identifiants: 99148658709311
Unité académique: Recherches translationnelles sur le VIH et les Maladies Infect. Endém. émerg. - TransVIHMI
Langue: English
Type de ressource: Journal article