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Solid phase synthesis of phosphonopeptides from Fmoc phosphonodipeptides
Article de revue scientifique   Avec comité de lecture

Solid phase synthesis of phosphonopeptides from Fmoc phosphonodipeptides

Dominique Maffre-Lafon, Roger Escale, Pascal Dumy, Jean-Pierre Vidal et Jean-Pierre Girard
Tetrahedron letters, Vol.35(24), p.4097-4098
13/06/1994

Résumé

allylic protection Fmoc strategy Phosphonodipeptide precursors Phosphonopeptide Solid phase
The solid phase synthesis of two phosphonopeptides was carried out from a N-Fmoc protected dipeptide precursor containing the PN bond and a benzyl or allyl carboxylic protection easily removable under neutral conditions. The solid phase synthesis of phosphonopeptides was obtained from free carboxy N-Fmoc phosphonodipeptides as precursors.

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