Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans

Geoffrey Canet; Felipe Da Gama Monteiro; Emma Rocaboy; Sofia Diego-Diaz; Boutheyna Khelaifia; Jessica Kim; Daphne Valencia; Audrey Yin; Hau-Tieng Wu; Jordan Howell; Emily Blank; Francis Laliberté; Nadia Fortin; Emmanuelle Boscher; Parissa Fereydouni-Forouzandeh; Stéphanie Champagne; Isabelle Guisle; Sébastien Hébert; Vincent Pernet; Haiyan Liu; William Lu; Ludovic Debure; David Rapoport; Indu Ayappa; Andrew Varga; Ankit Parekh; Ricardo Osorio; Steve Lacroix; Brendan Lucey; Esther Blessing; Emmanuel Planel

doi:10.21203/rs.3.rs-4384494/v1

Article de revue

Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans

Geoffrey Canet, Felipe Da Gama Monteiro, Emma Rocaboy, Sofia Diego-Diaz, Boutheyna Khelaifia, Jessica Kim, Daphne Valencia, Audrey Yin, Hau-Tieng Wu, Jordan Howell, …

Research square

14/05/2024

DOI: https://doi.org/10.21203/rs.3.rs-4384494/v1

PMID: 38798432

Résumé

sleep-wake cycle

tau

unconventional protein secretion

body temperature

Alzheimer’s disease

The sleep-wake cycle regulates interstitial fluid and cerebrospinal fluid (CSF) tau levels in both mouse and human by mechanisms that remain unestablished. Here, we reveal a novel pathway by which wakefulness increases extracellular tau levels in mouse and humans. In mice, higher body temperature (BT) associated with wakefulness and sleep deprivation increased CSF tau. , wakefulness temperatures upregulated tau secretion a temperature-dependent increase in activity and expression of unconventional protein secretion pathway-1 components, namely caspase-3-mediated C-terminal cleavage of tau (TauC3), and membrane expression of PIP and syndecan-3. In humans, the increase in both CSF and plasma tau levels observed post-wakefulness correlated with BT increase during wakefulness. Our findings suggest sleep-wake variation in BT may contribute to regulating extracellular tau levels, highlighting the importance of thermoregulation in pathways linking sleep disturbance to neurodegeneration, and the potential for thermal intervention to prevent or delay tau-mediated neurodegeneration.

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Détails

Titre: Sleep-wake body temperature regulates tau secretion in mice and correlates with CSF and plasma tau in humans
Créateurs - sans rôle: Geoffrey Canet - Research Center of CHU de Quebec - Laval University
Felipe Da Gama Monteiro - Research Center of CHU de Quebec - Laval University
Emma Rocaboy - Research Center of CHU de Quebec - Laval University
Sofia Diego-Diaz - Research Center of CHU de Quebec - Laval University
Boutheyna Khelaifia - Research Center of CHU de Quebec - Laval University
Jessica Kim - Department of Psychiatry, NYU Grossman School of Medicine
Daphne Valencia - Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai
Audrey Yin - Department of Psychiatry, NYU Grossman School of Medicine
Hau-Tieng Wu - Department of Psychiatry, NYU Grossman School of Medicine
Jordan Howell - Department of Psychiatry, NYU Grossman School of Medicine
Emily Blank - Department of Psychiatry, NYU Grossman School of Medicine
Francis Laliberté - Research Center of CHU de Quebec - Laval University
Nadia Fortin - Research Center of CHU de Quebec - Laval University
Emmanuelle Boscher - Centre de recherche du CHU de Québec-Université Laval
Parissa Fereydouni-Forouzandeh - Research Center of CHU de Quebec - Laval University
Stéphanie Champagne - Research Center of CHU de Quebec - Laval University
Isabelle Guisle
Sébastien Hébert - Centre de recherche du CHU de Québec - Université Laval, Axe neurosciences, Québec
Vincent Pernet - Department of Neurology, Bern University Hospital
Haiyan Liu - Washington University in St. Louis
William Lu - Department of Neurology, Washington University School of Medicine
Ludovic Debure - New York University
David Rapoport - Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai
Indu Ayappa - Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai
Andrew Varga - Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai
Ankit Parekh - Mount Sinai Integrative Sleep Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai
Ricardo Osorio - New York University School of Medicine
Steve Lacroix - Research Center of CHU de Quebec - Laval University
Brendan Lucey - Department of Neurology, Washington University School of Medicine
Esther Blessing - Department of Psychiatry, NYU Grossman School of Medicine
Emmanuel Planel - Centre de recherche du CHU de Québec - Université Laval, Axe neurosciences, Québec
Détails de publication: Research square
Note de subvention: K25 HL151912 / NHLBI NIH HHS K76 AG054863 / NIA NIH HHS R21 HL165320 / NHLBI NIH HHS R01 HL171813 / NHLBI NIH HHS R01 AG070866 / NIA NIH HHS R21 HL173733 / NHLBI NIH HHS
Identifiants: 99162999209311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article