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Short Enantioselective Syntheses of trans-5-Alkylprolines from New Functionalized Amino Alcohols
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Short Enantioselective Syntheses of trans-5-Alkylprolines from New Functionalized Amino Alcohols

Jeanne Alladoum, Sylvain Roland, Emmanuel Vrancken, Pierre Mangeney et Catherine Kadouri-Puchot
Journal of organic chemistry, Vol.2008(73), pp.9171-9774
19/12/2008
PMID: 18834177

Résumé

Chemical Sciences Organic chemistry
Amino alcohols, having an enol ether function, cyclized in acidic medium to give quantitatively diastereosomerically pure bicyclic compounds that were transformed in five steps in enantiopure trans-5-alkylproline derivatives.

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