Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Melissa A. Munn-Chernoff; Emma C. Johnson; Yi-Ling Chou; Jonathan R. I. Coleman; Laura M. Thornton; Raymond K. Walters; Zeynep Yilmaz; Jessica H. Baker; Christopher Hubel; Scott Gordon; Sarah E. Medland; Hunna J. Watson; Helena A. Gaspar; Julien Bryois; Anke Hinney; Virpi M. Leppa; Manuel Mattheisen; Stephan Ripke; Shuyang Yao; Paola Giusti-Rodriguez; Ken B. Hanscombe; Roger A. H. Adan; Lars Alfredsson; Tetsuya Ando; Ole A. Andreassen; Wade H. Berrettini; Ilka Boehm; Claudette Boni; Vesna Boraska Perica; Katharina Buehren; Roland Burghardt; Matteo Cassina; Sven Cichon; Maurizio Clementi; Roger D. Cone; Philippe Courtet; Scott Crow; James J. Crowley; Unna N. Danner; Oliver S. P. Davis; Martina de Zwaan; George Dedoussis; Daniela Degortes; Janiece E. DeSocio; Danielle M. Dick; Dimitris Dikeos; Christian Dina; Monika Dmitrzak-Weglarz; Elisa Docampo; Laramie E. Duncan; Karin Egberts; Stefan Ehrlich; Georgia Escaramis; Tonu Esko; Xavier Estivill; Anne Farmer; Angela Favaro; Fernando Fernandez-Aranda; Manfred M. Fichter; Krista Fischer; Manuel Foecker; Lenka Foretova; Andreas J. Forstner; Monica Forzan; Christopher S. Franklin; Steven Gallinger; Ina Giegling; Johanna Giuranna; Fragiskos Gonidakis; Philip Gorwood; Monica Gratacos Mayora; Sebastien Guillaume; Yiran Guo; Hakon Hakonarson; Konstantinos Hatzikotoulas; Joanna Hauser; Johannes Hebebrand; Sietske G. Helder; Stefan Herms; Beate Herpertz-Dahlmann; Wolfgang Herzog; Laura M. Huckins; James I. Hudson; Hartmut Imgart; Hidetoshi Inoko; Vladimir Janout; Susana Jimenez-Murcia; Antonio Julia; Gursharan Kalsi; Deborah Kaminska; Leila Karhunen; Andreas Karwautz; Martien J. H. Kas; James L. Kennedy; Anna Keski-Rahkonen; Kirsty Kiezebrink; Youl-Ri Kim; Kelly L. Klump; Gun Peggy S. Knudsen; Maria C. La Via

doi:10.1111/adb.12880

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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

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Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Melissa A. Munn-Chernoff, Emma C. Johnson, Yi-Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond K. Walters, Zeynep Yilmaz, Jessica H. Baker, Christopher Hubel, Scott Gordon, …

Addiction biology, Vol.26(1), pp.e12880-n/a

01/2021

DOI: https://doi.org/10.1111/adb.12880

PMID: 32064741

Résumé

Biochemistry & Molecular Biology

Life Sciences & Biomedicine

Science & Technology

Substance Abuse

Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r(g)], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from similar to 2400 to similar to 537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (r(g) = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (r(g) = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (r(g) = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (r(gs) = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.

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Titre: Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Créateurs - sans rôle: Melissa A. Munn-Chernoff - Univ North Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Emma C. Johnson - Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Yi-Ling Chou - Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA
Jonathan R. I. Coleman - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Laura M. Thornton - Univ North Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Raymond K. Walters - Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Zeynep Yilmaz - Univ North Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Jessica H. Baker - Univ North Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Christopher Hubel - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Scott Gordon - QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Sarah E. Medland - QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia
Hunna J. Watson - Univ North Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Helena A. Gaspar - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Julien Bryois - Karolinska Institutet
Anke Hinney - Univ DuisburgEssen, Univ Hosp Essen, Dept Child & Adolescent Psychiat, Essen, Germany
Virpi M. Leppa - Karolinska Institutet
Manuel Mattheisen - Aarhus Univ, Dept Biomed, Aarhus, Denmark
Stephan Ripke - Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA 02114 USA
Shuyang Yao - Karolinska Institutet
Paola Giusti-Rodriguez - Univ North Carolina, Dept Genet, Chapel Hill, NC 27515 USA
Ken B. Hanscombe - Kings Coll London, Guys Hosp, Dept Med & Mol Genet, London, England
Roger A. H. Adan - Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands
Lars Alfredsson - Karolinska Institutet
Tetsuya Ando - Natl Inst Mental Hlth, Natl Ctr Neurol & Psychiat, Dept Behav Med, Kodaira, Japan
Ole A. Andreassen - University of Oslo
Wade H. Berrettini - Univ Penn, Dept Psychiat, Perelman Sch Med, Ctr Neurobiol & Behav, Philadelphia, PA 19104 USA
Ilka Boehm - Tech Univ Dresden, Fac Med, Div Psychol & Social Med & Dev Neurosci, Dresden, Germany
Claudette Boni - Centre for Psychiatry and Neuroscience
Vesna Boraska Perica - Wellcome Genome Campus, Wellcome Sanger Inst, Cambridge, England
Katharina Buehren - Rhein Westfal TH Aachen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany
Roland Burghardt - Klinikum Frankfurt Oder, Frankfurt, Germany
Matteo Cassina - University of Padua
Sven Cichon - Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
Maurizio Clementi - University of Padua
Roger D. Cone - University of Michigan
Philippe Courtet - Univ Montpellier, CHRU Montpellier, Dept Emergency Psychiat & Postacute Care, Montpellier, France
Scott Crow - University of Minnesota
James J. Crowley - Univ North Carolina, Dept Genet, Chapel Hill, NC 27515 USA
Unna N. Danner - Altrecht Mental Hlth Inst, Altrecht Eating Disorders Rintveld, Zeist, Netherlands
Oliver S. P. Davis - University of Bristol
Martina de Zwaan - Hannover Med Sch, Dept Psychosomat Med & Psychotherapy, Hannover, Germany
George Dedoussis - Harokopio Univ, Dept Nutr & Dietet, Athens, Greece
Daniela Degortes - University of Padua
Janiece E. DeSocio - Seattle University
Danielle M. Dick - Virginia Commonwealth University
Dimitris Dikeos - Athens Univ, Sch Med, Dept Psychiat, Athens, Greece
Christian Dina - Univ Nantes, Inst Thorax, INSERM, CNRS, Nantes, France
Monika Dmitrzak-Weglarz - Poznan Univ Med Sciences, Dept Psychiat Genet, Poznan, Poland
Elisa Docampo - Barcelona Inst Sci & Technol, Barcelona, Spain
Laramie E. Duncan - Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
Karin Egberts - Univ Hosp Wurzburg, Ctr Mental Hlth, Dept Child & Adolescent Psychiat Psychosomat & Ps, Wurzburg, Germany
Stefan Ehrlich - Tech Univ Dresden, Fac Med, Div Psychol & Social Med & Dev Neurosci, Dresden, Germany
Georgia Escaramis - Barcelona Inst Sci & Technol, Barcelona, Spain
Tonu Esko - University of Tartu
Xavier Estivill - Barcelona Inst Sci & Technol, Barcelona, Spain
Anne Farmer - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Angela Favaro - Univ Padua, Dept Neurosci, Padua, Italy
Fernando Fernandez-Aranda - Univ Hosp Bellvitge, Dept Psychiat, IDIBELL, Barcelona, Spain
Manfred M. Fichter - Ludwig Maximilians Univ Munchen, Dept Psychiat & Psychotherapy, Munich, Germany
Krista Fischer - University of Tartu
Manuel Foecker - Univ Munster, Dept Child & Adolescent Psychiat, Munster, Germany
Lenka Foretova - Masaryk Mem Canc Inst, Dept Canc Epidemiol & Genet, Brno, Czech Republic
Andreas J. Forstner - Univ Basel, Dept BioMed, Basel, Switzerland
Monica Forzan - University of Padua
Christopher S. Franklin - Wellcome Sanger Institute
Steven Gallinger - University of Toronto
Ina Giegling - Martin Luther University Halle-Wittenberg
Johanna Giuranna - Univ DuisburgEssen, Univ Hosp Essen, Dept Child & Adolescent Psychiat, Essen, Germany
Fragiskos Gonidakis - National and Kapodistrian University of Athens
Philip Gorwood - Institut de Psychiatrie et Neurosciences de Paris
Monica Gratacos Mayora - Barcelona Inst Sci & Technol, Barcelona, Spain
Sebastien Guillaume - Univ Montpellier, CHRU Montpellier, Dept Emergency Psychiat & Postacute Care, Montpellier, France
Yiran Guo - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Hakon Hakonarson - Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA
Konstantinos Hatzikotoulas - Wellcome Sanger Institute
Joanna Hauser - Poznan Univ Med Sciences, Dept Adult Psychiat, Poznan, Poland
Johannes Hebebrand - Univ DuisburgEssen, Univ Hosp Essen, Dept Child & Adolescent Psychiat, Essen, Germany
Sietske G. Helder - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Stefan Herms - Univ Hosp Basel, Inst Med Genet & Pathol, Basel, Switzerland
Beate Herpertz-Dahlmann - Rhein Westfal TH Aachen, Dept Child & Adolescent Psychiat Psychosomat & Ps, Aachen, Germany
Wolfgang Herzog - Heidelberg Univ, Heidelberg Univ Hosp, Dept Gen Internal Med & Psychosomat, Heidelberg, Germany
Laura M. Huckins - Wellcome Genome Campus, Wellcome Sanger Inst, Cambridge, England
James I. Hudson - Harvard Med Sch, McLean Hosp, Biol Psychiat Lab, Boston, MA 02115 USA
Hartmut Imgart - Parklandklinik, Eating Disorders Unit, Bad Wildungen, Germany
Hidetoshi Inoko - Tokai University
Vladimir Janout - Palacky Univ, Fac Hlth Sci, Olomouc, Czech Republic
Susana Jimenez-Murcia - Univ Hosp Bellvitge, Dept Psychiat, IDIBELL, Barcelona, Spain
Antonio Julia - Vall d'Hebron Institut de Recerca
Gursharan Kalsi - Kings Coll London, Inst Psychiat Psychol & Neurosci, SGDP Ctr, London, England
Deborah Kaminska - Charles University
Leila Karhunen - University of Eastern Finland
Andreas Karwautz - University of Vienna
Martien J. H. Kas - Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht, Netherlands
James L. Kennedy - Ctr Addict & Mental Hlth, Toronto, ON, Canada
Anna Keski-Rahkonen - University of Helsinki
Kirsty Kiezebrink - University of Aberdeen
Youl-Ri Kim - Inje Univ, Seoul Paik Hosp, Dept Psychiat, Seoul, Seoul, South Korea
Kelly L. Klump - Michigan State University
Gun Peggy S. Knudsen - Norwegian Inst Publ Hlth, Dept Mental Disorders, Oslo, Norway
Maria C. La Via - Univ North Carolina, Dept Psychiat, 101 Manning Dr,Campus Box 7160, Chapel Hill, NC 27515 USA
Détails de publication: Addiction biology, Vol.26(1), pp.e12880-n/a
Éditeur: Wiley
Nombre de pages: 20
Note de subvention: R248-2017-2003; R155-2014-1724 / Lundbeck Foundation; Lundbeckfonden MC_UU_00007/10 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) R01MH123619 / National Institute of Mental Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) R01HD093651 / Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) K02DA032573 / National Institute on Drug Abuse; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA) MC_UU_00007/10 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) K01AA025113 / National Institute on Alcohol Abuse and Alcoholism; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) R01GM126479 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
Identifiants: 99139444309311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article