Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis

Saskia A. Bode; Marion Thevenin; Cherine Bechara; Sandrine Sagan; Sarah Bregant; Solange Lavielle; Gerard Chassaing; Fabienne Burlina

doi:10.1039/c2cc33240j

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Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis

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Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis

Saskia A. Bode, Marion Thevenin, Cherine Bechara, Sandrine Sagan, Sarah Bregant, Solange Lavielle, Gerard Chassaing et Fabienne Burlina

Chemical communications (Cambridge, England), Vol.48(57), pp.7179-7181

21/07/2012

DOI: https://doi.org/10.1039/c2cc33240j

PMID: 22692031

Résumé

Chemistry

Chemistry, Multidisciplinary

Physical Sciences

Science & Technology

A small library of cell-penetrating peptides (CPPs) containing a minimized cationic domain and a lipophilic domain of different size was studied. CPPs that could self-assemble were found to enter cells more efficiently, triggering a glycosaminoglycan-dependent pathway.

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Détails

Titre: Self-assembling mini cell-penetrating peptides enter by both direct translocation and glycosaminoglycan-dependent endocytosis
Créateurs - sans rôle: Saskia A. Bode - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Marion Thevenin - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Cherine Bechara - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Sandrine Sagan - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Sarah Bregant - CEA, SIMOPRO, IBiTec S, F-91191 Gif Sur Yvette, France
Solange Lavielle - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Gerard Chassaing - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Fabienne Burlina - Univ Paris 06, UPMC, UMR 7203, LBM, F-75005 Paris, France
Détails de publication: Chemical communications (Cambridge, England), Vol.48(57), pp.7179-7181
Éditeur: Royal Soc Chemistry
Nombre de pages: 3
Identifiants: 99139576309311
Unité académique: Institut de Génomique Fonctionnelle - IGF
Langue: English
Type de ressource: Journal article