Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis

Jean-Charles Maillard; David Berthier; Isabelle Chantal; Sophie Thevenon; Issa Sidibé; Frederic Stachurski; Désiré Belemsaga; Hanta Razafindraïbé; Jean-Michel Elsen

doi:10.1186/1297-9686-35-S1-S193

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Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis

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Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis

Jean-Charles Maillard, David Berthier, Isabelle Chantal, Sophie Thevenon, Issa Sidibé, Frederic Stachurski, Désiré Belemsaga, Hanta Razafindraïbé et Jean-Michel Elsen

Genetics selection evolution (Paris), Vol.35(Suppl 1), pp.S193-S200

15/06/2003

DOI: https://doi.org/10.1186/1297-9686-35-S1-S193

PMID: 12927091

Résumé

Bovine dermatophilosis is a severe skin infection of tropical ruminants inducing a severe loss in productivity and a 15% mortality rate. This disease is caused by the actinomycete bacterium Dermatophilus congolensis associated with the tick Amblyomma variegatum. Currently there are no prospects for a vaccine, and acaricide or antibiotic control is hampered by the development of chemoresistance. Animal breeders have observed that dermatophilosis susceptibility seems to be determined genetically, and we previously identified a BoLA-DRB3-DQB class II haplotype marker for high (R2 = 0.96) susceptibility to the disease. With this marker, we developed a successful eugenic selection procedure for zebu Brahman cattle in Martinique (FWI). Over a period of five years, a marked reduction in disease prevalence, from 0.76 to 0.02 was achieved, and this low level has been maintained over the last two years. The selection procedure, based on a genetic marker system targeting the highly polymorphic BoLA locus, eliminates only those individuals which are at the highest risk of contracting the disease. In the present work, we discuss the properties of this system, including the "heterozygote advantage" and the "frequency dependence" theories, and examine their involvement in the biological mechanisms at the host/pathogen interface. We speculate on the exact role of the MHC molecules in the control of the disease, how the natural selection pressure imposed by the pathogens selectively maintains MHC diversity, and how our results can be practically applied for integrated control of dermatophilosis in developing countries.

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Détails

Titre: Selection assisted by a BoLA-DR/DQ haplotype against susceptibility to bovine dermatophilosis
Créateurs - sans rôle: Jean-Charles Maillard - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
David Berthier - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Isabelle Chantal - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Sophie Thevenon - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Issa Sidibé - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Frederic Stachurski - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Désiré Belemsaga - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Hanta Razafindraïbé - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Jean-Michel Elsen - Cirad – Département d'Élevage et de Médecine Vétérinaire Tropicale, Animal Health Program, Montpellier, France Cirdes, Unité de Recherches Biologiques, Bobo-Dioulasso, Burkina Faso Fofifa – Département de Recherches Zootechniques et Vétérinaires, Antananarivo, Madagascar Inra – Station d'Amélioration Génétique Animale, Castanet-Tolosan, France
Détails de publication: Genetics selection evolution (Paris), Vol.35(Suppl 1), pp.S193-S200
Éditeur: BioMed Central
Identifiants: 99155112509311
Unité académique: Intéractions hôtes-vecteurs-parasites-environnement maladies tropicales - INTERTRYP
Langue: English
Type de ressource: Journal article