Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy

F. Poumeaud; T. Valentin; N. Fares; B. Segier; S. Watson; B. Verret; C. Tlemsani; N. Penel; S. Lejeune; N. Firmin; A. Sabouret; J.-C. Thery; S. Bonvalot; E. Cottereau; E. Cauchin; A. Lancon; S. Nambot; H. Zattara; M. Coudert; E. Fourme; C. Nogues; D. Tougeron; F. Prieur; M.-A. Collonge-Rame; C. Denis; P. Laurent-Puig; S. Chieze-Valero; H. Dreyfus; M. Jaffrelot; P. Vande Perre; P. Rochaix; A. Gomez-Mascard; P. Rochefort; S. Campoy; Frédéric Chibon; C. Lasset; J. Selves; R. Guimbaud

doi:10.1016/j.ejca.2024.115196

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Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy

Journal article

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Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy

F. Poumeaud, T. Valentin, N. Fares, B. Segier, S. Watson, B. Verret, C. Tlemsani, N. Penel, S. Lejeune, N. Firmin, …

European Journal of Cancer, Vol.216

2024

DOI: https://doi.org/10.1016/j.ejca.2024.115196

PMID: 39742560

Abstract

Deficient mismatch repair

Immune checkpoint inhibitors

Lynch Syndrome

MSH2

Microsatellite instability

Pleomorphic rhabdomyosarcomas

Sarcomas do not belong to the Lynch Syndrome (LS)-tumour spectrum. A growing body literature has reported sarcomas in patients with LS. Clinical and tumour characteristics of these patients remain unknown.

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Title: Sarcomas developed in patients with Lynch Syndrome are enriched in pleomorphic soft-tissue sarcomas and are sensitive to immunotherapy
Creators - without role: F. Poumeaud - Pôle IUCT [CHU Toulouse]
T. Valentin - Institut universitaire du cancer de Toulouse Oncopole
N. Fares - Centre de Recherche en Cancérologie de Toulouse
B. Segier - Institut Claudius Regaud
S. Watson - Institut Curie
B. Verret - Institut Gustave Roussy
C. Tlemsani - Assistance Publique – Hôpitaux de Paris
N. Penel - Centre Oscar Lambret
S. Lejeune - Hôpital Jeanne de Flandre
N. Firmin - Université de Montpellier, Institut de Recherche en Cancérologie de Montpellier - IRCM
A. Sabouret - Institut Curie
J.-C. Thery - Montreal Neurological Institute and Hospital
S. Bonvalot - Institut Curie
E. Cottereau - Institut de Physique
E. Cauchin - Institut de Cancérologie de l'Ouest
A. Lancon - Centre Georges François Leclerc
S. Nambot - Centre Hospitalier Universitaire Dijon Bourgogne
H. Zattara - Assistance Publique Hôpitaux de Marseille
M. Coudert - Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail
E. Fourme - Institut Claudius Regaud
C. Nogues - Institut Paoli-Calmettes
D. Tougeron - Université de Poitiers
F. Prieur - Centre Hospitalier Universitaire de Saint-Étienne
M.-A. Collonge-Rame - Centre Hospitalier Universitaire de Besançon
C. Denis - Université de Strasbourg
P. Laurent-Puig - Institut Gustave Roussy
S. Chieze-Valero - Centre Hospitalier de Niort
H. Dreyfus - Institut Sainte Catherine
M. Jaffrelot - Institut Claudius Regaud
P. Vande Perre - Institut Claudius Regaud
P. Rochaix - Centre de Recherche en Cancérologie de Toulouse
A. Gomez-Mascard - Centre de Recherche en Cancérologie de Toulouse
P. Rochefort - Centre Léon Bérard
S. Campoy - Centre Léon Bérard
Frédéric Chibon - Centre de Recherche en Cancérologie de Toulouse
C. Lasset - Centre Léon Bérard
J. Selves - Centre de Recherche en Cancérologie de Toulouse
R. Guimbaud - Pôle IUCT [CHU Toulouse]
Publication Details: European Journal of Cancer, Vol.216
Identifiers: 9940010009311
Academic Unit: Institut de Recherche en Cancérologie de Montpellier - IRCM
Language: English
Resource Type: Journal article
Local Fields: hal-04966169