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Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype
Article de revue   Avec comité de lecture

Salmonella enterica Serotype Typhi with nonclassical quinolone resistance phenotype

Marie Accou-Demartin, Valérie Gaborieau, Yajun Song, Philippe Roumagnac, Bruno Marchou, Mark Achtman et François-Xavier Weill
Emerging infectious diseases, Vol.17(6), pp.1091-4
01/06/2011
DOI: https://doi.org/10.3201/eid1706.101242
PMID: 21749778

Résumé

Anti-Bacterial Agents Bacteriology Drug Resistance, Bacterial Gene Expression Regulation, Bacterial Genes, Bacterial Haplotypes Humans Life Sciences Microbial Sensitivity Tests Microbiology and Parasitology Mutation Phenotype Quinolones Salmonella typhi Typhoid Fever
We report Salmonella enterica serotype Typhi strains with a nonclassical quinolone resistance phenotype (i.e., decreased susceptibility to ciprofloxacin but with susceptibility to nalidixic acid) associated with a nonsynonymous mutation at codon 464 of the gyrB gene. These strains, not detected by the nalidixic acid disk screening test, can result in fluoroquinolone treatment failure.

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