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SYSTEMS BIOLOGY ANALYSIS OF KINASE INHIBITOR ACTION IN LEUKEMIA TREATMENTS
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SYSTEMS BIOLOGY ANALYSIS OF KINASE INHIBITOR ACTION IN LEUKEMIA TREATMENTS

Jacques Colinge
Biomedizinische Technik, Vol.58
01/08/2013
PMID: 24042955

Résumé

Engineering Engineering, Biomedical Life Sciences & Biomedicine Medical Informatics Science & Technology Technology
We propose a new computational method of relating kinase inhibitor protein targets to genetic defects associated to a disease through protein interaction network-based random walks. We illustrate the potential of this methods on two forms of leukemia chronic myeloid and Philadelphia positive acute lymphoblastic.

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