Abstract
Surface-modified liposomes with specific bone-targeting properties are promising alternatives to classical medication, thanks to their reduced systemic toxicity. In this paper, the synthesis of an amphiphilic compound containing a hydroxybisphosphonic acid (HBPA) group as hydrophilic part is reported. The compound has been prepared starting from its carboxylic acid correspondent, by conversion in its corresponding acid chloride, followed by its reaction with tris(trimethylsilyl) phosphite and then methanolysis of the silylated intermediate. A detailed description of the registered analyses that confirm product structure is also provided. Compounds with similar structure are known to enable the liposomes containing them to specifically bind to hydroxyapatite (HA) of bones.