Abstract
Post-translational modifiers of the SUMO (Small Ubiquitin-related Modifier) family have emergedas key regulators of protein function and fate. While the past few years have seen an enormousincrease in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review will provide anoverview on recent advances concerning (i) the interplay between sumoylation and other post-translational modifications at the level of individual targets and (ii) global regulation of SUMOconjugation and deconjugation.