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STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
Article de revue

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development

Andre Limnander, Philippe Depeille, Tanya S Freedman, Jen Liou, Michael Leitges, Tomohiro Kurosaki, Jeroen P Roose et Arthur Weiss
Nature Immunology, Vol.12(5), pp.425-433
01/05/2011

Résumé

1.1 Normal biological development and functioning (hrcs-rac) 1107 Immunology (for) 2.1 Biological and endogenous factors (hrcs-rac) 31 Biological Sciences (for-2020) 3101 Biochemistry and Cell Biology (for-2020) 32 Biomedical and Clinical Sciences (for-2020) 3204 Immunology (for-2020) Animals (mesh) Apoptosis (mesh) B-Lymphocytes (mesh) Calcium Channels (mesh) Cell Line (mesh) Developmental (mesh) Enzyme Activation (mesh) Extracellular Signal-Regulated MAP Kinases (mesh) Flow Cytometry (mesh) Gene Expression Regulation Guanine Nucleotide Exchange Factors (mesh) Immunoblotting (mesh) Immunology (science-metrix) Inbred C57BL (mesh) Knockout (mesh) Membrane Glycoproteins (mesh) Mice Mice (mesh) Phosphorylation (mesh) Protein Kinase C-delta (mesh) Signal Transduction (mesh) Stromal Interaction Molecule 1 (mesh)
Developing B cells show enhanced sensitivity to negatively selecting signals. Weiss and colleagues show that calcium signals arising from activation of the calcium sensor STIM1 lead to activation of Erk and apoptosis via a protein kinase C-δ and the guanine nucleotide-exchange factor RasGRP1-dependent pathway in transitional self-reactive B cells.

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