SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo

Ilaria Dorigatti; Enrico Lavezzo; Laura Manuto; Constanze Ciavarella; Monia Pacenti; Caterina Boldrin; Margherita Cattai; Francesca Saluzzo; Elisa Franchin; Claudia Del Vecchio; Federico Caldart; Gioele Castelli; Michele Nicoletti; Eleonora Nieddu; Elisa Salvadoretti; Beatrice Labella; Ludovico Fava; Simone Guglielmo; Mariateresa Fascina; Marco Grazioli; Gualtiero Alvisi; Maria Cristina Vanuzzo; Tiziano Zupo; Reginetta Calandrin; Vittoria Lisi; Lucia Rossi; Ignazio Castagliuolo; Stefano Merigliano; H. Juliette T. Unwin; Mario Plebani; Andrea Padoan; Alessandra R. Brazzale; Stefano Toppo; Neil M. Ferguson; Christl A. Donnelly; Andrea Crisanti

doi:10.1038/s41467-021-24622-7

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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo

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SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo

Ilaria Dorigatti, Enrico Lavezzo, Laura Manuto, Constanze Ciavarella, Monia Pacenti, Caterina Boldrin, Margherita Cattai, Francesca Saluzzo, Elisa Franchin, Claudia Del Vecchio, …

Nature communications, Vol.12(1), pp.4383-11

19/07/2021

DOI: https://doi.org/10.1038/s41467-021-24622-7

PMID: 34282139

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In February and March 2020, two mass swab testing campaigns were conducted in Vo’, Italy. In May 2020, we tested 86% of the Vo’ population with three immuno-assays detecting antibodies against the spike and nucleocapsid antigens, a neutralisation assay and Polymerase Chain Reaction (PCR). Subjects testing positive to PCR in February/March or a serological assay in May were tested again in November. Here we report on the results of the analysis of the May and November surveys. We estimate a seroprevalence of 3.5% (95% Credible Interval (CrI): 2.8–4.3%) in May. In November, 98.8% (95% Confidence Interval (CI): 93.7–100.0%) of sera which tested positive in May still reacted against at least one antigen; 18.6% (95% CI: 11.0–28.5%) showed an increase of antibody or neutralisation reactivity from May. Analysis of the serostatus of the members of 1,118 households indicates a 26.0% (95% CrI: 17.2–36.9%) Susceptible-Infectious Transmission Probability. Contact tracing had limited impact on epidemic suppression. Vo’, Italy, is a unique setting for studying SARS-CoV-2 antibody dynamics because mass testing was conducted there early in the pandemic. Here, the authors perform two follow-up serological surveys and estimate seroprevalence, the extent of within-household transmission, and the impact of contact tracing.

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Titre: SARS-CoV-2 antibody dynamics and transmission from community-wide serological testing in the Italian municipality of Vo
Créateurs - sans rôle: Ilaria Dorigatti - MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London
Enrico Lavezzo - Department of Molecular Medicine, University of Padova
Laura Manuto - Department of Molecular Medicine, University of Padova
Constanze Ciavarella - MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London
Monia Pacenti - Azienda Ospedale Padova
Caterina Boldrin - Azienda Ospedale Padova
Margherita Cattai - Azienda Ospedale Padova
Francesca Saluzzo - Department of Molecular Medicine, University of Padova
Elisa Franchin - Department of Molecular Medicine, University of Padova
Claudia Del Vecchio - Department of Molecular Medicine, University of Padova
Federico Caldart - Department of Molecular Medicine, University of Padova
Gioele Castelli - Department of Molecular Medicine, University of Padova
Michele Nicoletti - Department of Molecular Medicine, University of Padova
Eleonora Nieddu - Department of Molecular Medicine, University of Padova
Elisa Salvadoretti - Department of Molecular Medicine, University of Padova
Beatrice Labella - Department of Molecular Medicine, University of Padova
Ludovico Fava - Department of Molecular Medicine, University of Padova
Simone Guglielmo - Department of Molecular Medicine, University of Padova
Mariateresa Fascina - Department of Molecular Medicine, University of Padova
Marco Grazioli - Department of Molecular Medicine, University of Padova
Gualtiero Alvisi - Department of Molecular Medicine, University of Padova
Maria Cristina Vanuzzo - Azienda Ospedale Padova
Tiziano Zupo - Azienda Ospedale Padova
Reginetta Calandrin - Azienda Ospedale Padova
Vittoria Lisi - Azienda Ospedale Padova
Lucia Rossi - Azienda Ospedale Padova
Ignazio Castagliuolo - Department of Molecular Medicine, University of Padova
Stefano Merigliano - Department of Surgery, Oncology and Gastroenterology, University of Padova
H. Juliette T. Unwin - MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London
Mario Plebani - Department of Medicine, University of Padova
Andrea Padoan - Department of Medicine, University of Padova
Alessandra R. Brazzale - Department of Statistical Sciences, University of Padova
Stefano Toppo - Department of Molecular Medicine, University of Padova, CRIBI Biotech Centre, University of Padova
Neil M. Ferguson - MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London
Christl A. Donnelly - MRC Centre for Global Infectious Disease Analysis and the Abdul Latif Jameel Institute for Disease and Emergency Analytics, School of Public Health, Imperial College London, Department of Statistics, University of Oxford
Andrea Crisanti - Department of Molecular Medicine, University of Padova, Azienda Ospedale Padova, Department of Life Science Imperial College London, Exhibition Road
Détails de publication: Nature communications, Vol.12(1), pp.4383-11
Éditeur: Nature Publishing Group UK
Note de subvention: MR/R015600/1 / RCUK | MRC | Medical Research Foundation (https://doi.org/10.13039/501100009187) 213494/Z/18/Z / Wellcome Trust (Wellcome) (https://doi.org/10.13039/100004440) 874735; 874735 / EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) (https://doi.org/10.13039/100010661)
Identifiants: 99156951509311
Unité académique: Pathogenesis and Control of Chronic and Emerging Infections - PCCEI
Langue: English
Type de ressource: Journal article