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Ruthenium-Catalyzed Tandem C-H Fluoromethylation/Cyclization of N-Alkylhydrazones with CBr3F: Access to 4-Fluoropyrazoles
Article de revue   Avec comité de lecture

Ruthenium-Catalyzed Tandem C-H Fluoromethylation/Cyclization of N-Alkylhydrazones with CBr3F: Access to 4-Fluoropyrazoles

Alexis Prieto, Didier Bouyssi et Nuno Monteiro
Journal of organic chemistry, Vol.82(6), pp.3311-3316
17/03/2017
DOI: https://doi.org/10.1021/acs.joc.7b00085
PMID: 28263600

Résumé

Chemistry Chemistry, Organic Physical Sciences Science & Technology
4-Fluoropyrazoles are accessible in a single step from readily available aldehyde-derived N-alkylhydrazones through double C-H fluoroalkylation with tribromofluoromethane (CBr3F). RuCl2(PPh3)(3) has been proven to be the most efficient catalyst for this transformation when compared to a range of other Cu-, Pd-, or Fe-based catalyst systems.

Indicateurs

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