Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study

Sheraz Markar; Caroline Gronnier; Arnaud Pasquer; Alain Duhamel; Hélène Beal; Jérémie Thereaux; Johan Gagnière; Gil Lebreton; Cécile Brigand; B. Meunier; Denis Collet; Christophe Mariette; Abdennahceur Dhahri; Delphine Lignier; Cyril Cossé; Marc Regimbeau; Magalie Cabau; Jacques Jougon; Bogdan Badic; Patrick Lozach; Pierre Bail; Serge Cappeliez; Issam El Nakadi; Arnaud Alves; Renaud Flamein; Denis Pezet; Federica Pipitone; Bogdan Stan-Iuga; Nicolas Contival; Eric Pappalardo; Simon Msika; Styliani Mantziari; Nicolas Demartines; Flora Hec; Marguerite Vanderbeken; Williams Tessier; Nicolas Briez; Fabien Fredon; Alain Gainant; Muriel Mathonnet; Marc Bigourdan; Salim Mezoughi; Christian Ducerf; Jacques Baulieux; Jean-Yves Mabrut; Oussama Baraket; Gilles Poncet; Mustapha Adam; Delphine Vaudoyer; Peggy Jourdan Enfer; Laurent Villeneuve; Olivier Glehen; Thibault Coste; Michel Fabre; Frédéric Marchal; Romain Frisoni; Ahmet Ayav; Laurent Brunaud; Laurent Bresler; Charlotte Cohen; Olivier Aze; Nicolas Venissac; Daniel Pop; Jerôme Mouroux; Ion Donici; Michel Prudhomme; Emanuele Felli; Stéphanie Lisunfui; Marie Seman; Gaelle Godiris Petit; Mehdi Karoui; Christophe Trésallet; Fabrice Menegaux; Jean-Christophe Vaillant; Laurent Hannoun; Brice Malgras; Denis Lantuas; Karine Pautrat; Marc Pocard; Patrice Valleur; Najim Chafai; Pierre Balladur; Magalie Lefrancois; Yann Parc; François Paye; Emmanuel Tiret; Marius Nedelcu; Letizia Laface; Thierry Perniceni; Brice Gayet; Alexandre Filipello; Jack Porcheron; Olivier Tiffet; Noémie Kamlet; Rodrigue Chemaly; Amandine Klipfel; Patrick Pessaux; Serge Rohr; Nicolas Carrère; Chiara da Re; FREGAT working group – FRENCH – AFC

doi:10.1016/j.ejca.2015.11.024

Retour

Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study

Article de revue

Avec comité de lecture

Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study

Sheraz Markar, Caroline Gronnier, Arnaud Pasquer, Alain Duhamel, Hélène Beal, Jérémie Thereaux, Johan Gagnière, Gil Lebreton, Cécile Brigand, B. Meunier, …

European journal of cancer (1990), Vol.56, pp.59-68

01/03/2016

DOI: https://doi.org/10.1016/j.ejca.2015.11.024

PMID: 26808298

Résumé

Cancer

Life Sciences

Aims: The aims of this study were to compare short-and long-term outcomes for clinical T2N0 oesophageal cancer with analysis of (i) primary surgery (S) versus neoadjuvant therapy plus surgery (NS), (ii) squamous cell carcinoma and adenocarcinoma subsets; and (iii) neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy.Methods: Data were collected from 30 European centres from 2000 to 2010. Among 2944 included patients, 355 patients (12.1%) had cT2N0 disease; 285 (S) and 70 (NS), were compared in terms of short-and long-term outcomes. Propensity score matching analyses were used to compensate for differences in baseline characteristics.Results: No significant differences between the groups were shown in terms of in hospital morbidity and mortality. Nodal disease was observed in 50% of S-group at the time of surgery, with 20% pN2/N3. Utilisation of neoadjuvant therapy was associated with significant tumour downstaging as reflected by increases in pT0, pN0 and pTNM stage 0 disease, this effect was further enhanced with neoadjuvant chemoradiotherapy. After adjustment on propensity score and confounding factors, for all patients and subset analysis of squamous cell and adenocarcinoma, neoadjuvant therapy had no significant effect upon survival or recurrence (overall, loco-regional, distant or mixed) compared to surgery alone. There were no significant differences between neoadjuvant chemotherapy and chemoradiotherapy in short-or long-term outcomes.Conclusion: The results of this study suggest that a surgery alone treatment approach should be recommended as the primary treatment approach for cT2N0 oesophageal cancer despite 50% of patients having nodal disease at the time of surgery.

Indicateurs

1 Consultations de la notice

Détails

Titre: Role of neoadjuvant treatment in clinical T2N0M0 oesophageal cancer: results from a retrospective multi-center European study
Créateurs - sans rôle: Sheraz Markar - Imperial College London
Caroline Gronnier - Centre de Recherche Jean Pierre Aubert
Arnaud Pasquer - Hôpital Edouard Herriot
Alain Duhamel - Site de Recherche Intégrée en Cancérologie
Hélène Beal - Site de Recherche Intégrée en Cancérologie
Jérémie Thereaux - Sans affiliation
Johan Gagnière - Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand]
Gil Lebreton - Hôpital Côte de Nacre [CHU Caen]
Cécile Brigand - Hôpital de Hautepierre [Strasbourg]
B. Meunier - Service de Chirurgie Hépatobiliaire et Digestive [Rennes] = Hepatobiliary and Digestive Surgery [Rennes]
Denis Collet - Sans affiliation
Christophe Mariette - Centre de Recherche Jean Pierre Aubert
Abdennahceur Dhahri - Ingénierie des Matériaux Polymères
Delphine Lignier - Sans affiliation
Cyril Cossé - Sans affiliation
Marc Regimbeau - Sans affiliation
Magalie Cabau - Sans affiliation
Jacques Jougon - Sans affiliation
Bogdan Badic - Sans affiliation
Patrick Lozach - Sans affiliation
Pierre Bail - Université de Brest
Serge Cappeliez - Sans affiliation
Issam El Nakadi - Sans affiliation
Arnaud Alves - Sans affiliation
Renaud Flamein - Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand]
Denis Pezet - Service Chirurgie Digestive et Hépatobiliaire [CHU Clermont-Ferrand]
Federica Pipitone - Sans affiliation
Bogdan Stan-Iuga - Centre de recherche sur l'Inflammation
Nicolas Contival - Sans affiliation
Eric Pappalardo - Sans affiliation
Simon Msika - Hôpital Louis-Mourier
Styliani Mantziari - Sans affiliation
Nicolas Demartines - Sans affiliation
Flora Hec - Sans affiliation
Marguerite Vanderbeken - Sans affiliation
Williams Tessier - Sans affiliation
Nicolas Briez - Sans affiliation
Fabien Fredon - Sans affiliation
Alain Gainant - Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges]
Muriel Mathonnet - Homéostasie Cellulaire et Pathologies
Marc Bigourdan - Sans affiliation
Salim Mezoughi - Sans affiliation
Christian Ducerf - Université Pierre et Marie Curie - Paris 6 - UFR de Médecine Pierre et Marie Curie
Jacques Baulieux - Sans affiliation
Jean-Yves Mabrut - Sans affiliation
Oussama Baraket - Sans affiliation
Gilles Poncet - Sans affiliation
Mustapha Adam - Environnement, Ville, Société
Delphine Vaudoyer - Sans affiliation
Peggy Jourdan Enfer - Sans affiliation
Laurent Villeneuve - Pôle Information Médicale Evaluation Recherche
Olivier Glehen - Centre Hospitalier Lyon Sud [CHU - HCL]
Thibault Coste - Sans affiliation
Michel Fabre - Centre de recherche en éducation de Nantes
Frédéric Marchal - Centre de Recherche en Automatique de Nancy
Romain Frisoni - Sans affiliation
Ahmet Ayav - Centre Hospitalier Régional Universitaire de Nancy
Laurent Brunaud - Nutrition-Génétique et Exposition aux Risques Environnementaux
Laurent Bresler - Centre Hospitalier Régional Universitaire de Nancy
Charlotte Cohen - Chelsea and Westminster Hospital
Olivier Aze - Sans affiliation
Nicolas Venissac - Sans affiliation
Daniel Pop - Universitatea de Vest din Timișoara [România] = West University of Timișoara [Romania] = Université Ouest de Timișoara [Roumanie]
Jerôme Mouroux - Sans affiliation
Ion Donici - Sans affiliation
Michel Prudhomme - Sans affiliation
Emanuele Felli - Sans affiliation
Stéphanie Lisunfui - Sans affiliation
Marie Seman - Sans affiliation
Gaelle Godiris Petit - Lab-STICC_UBS_CID_DECIDE
Mehdi Karoui - Service d'hépato-gastro-entérologie [APHP Henri Mondor]
Christophe Trésallet - CHU Pitié-Salpêtrière [AP-HP]
Fabrice Menegaux - CHU Pitié-Salpêtrière [AP-HP]
Jean-Christophe Vaillant - Laboratoire de Mathématiques Informatique et Applications
Laurent Hannoun - CHU Pitié-Salpêtrière [AP-HP]
Brice Malgras - Sans affiliation
Denis Lantuas - Sans affiliation
Karine Pautrat - Sans affiliation
Marc Pocard - Sans affiliation
Patrice Valleur - Sans affiliation
Najim Chafai - CHU Saint-Antoine [AP-HP]
Pierre Balladur - Centre de Recherche Saint-Antoine
Magalie Lefrancois - CHU Saint-Antoine [AP-HP]
Yann Parc - CHU Saint-Antoine [AP-HP]
François Paye - CHU Saint-Antoine [AP-HP]
Emmanuel Tiret - CHU Saint-Antoine [AP-HP]
Marius Nedelcu - Centre Hospitalier Régional Universitaire [Montpellier]
Letizia Laface - Sans affiliation
Thierry Perniceni - Sans affiliation
Brice Gayet - Sans affiliation
Alexandre Filipello - Sans affiliation
Jack Porcheron - Sans affiliation
Olivier Tiffet - Sans affiliation
Noémie Kamlet - Sans affiliation
Rodrigue Chemaly - Sans affiliation
Amandine Klipfel - Sans affiliation
Patrick Pessaux - Institut de Recherche sur les Maladies Virales et Hépatiques
Serge Rohr - Sans affiliation
Nicolas Carrère - Sans affiliation
Chiara da Re - Sans affiliation
FREGAT working group – FRENCH – AFC
Détails de publication: European journal of cancer (1990), Vol.56, pp.59-68
Éditeur: Elsevier
Nombre de pages: 10
Identifiants: 99153856109311
Unité académique: Initial MAnagement & prevent of acute orGan failures IN critically ill patiEnts - IMAGINE
Langue: English
Type de ressource: Journal article