Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

Nasim Mavaddat; Antonis Antoniou; Thea Mooij; Maartje Hooning; Bernadette Heemskerk-Gerritsen; Catherine Noguès; Marion Gauthier-Villars; Olivier Caron; Paul Gesta; Pascal Pujol; Alain Lortholary; Daniel Barrowdale; Debra Frost; D. Gareth Evans; Louise Izatt; Julian Adlard; Ros Eeles; Carole Brewer; Marc Tischkowitz; Alex Henderson; Jackie Cook; Diana Eccles; Klaartje van Engelen; Marian Mourits; Margreet Ausems; Linetta Koppert; John Hopper; Esther John; Wendy Chung; Irene Andrulis; Mary Daly; Saundra Buys; Javier Benitez; Trinidad Caldés; Anna Jakubowska; Jacques Simard; Christian Singer; Yen Tan; Edith Olah; Marie Navratilova; Lenka Foretova; Anne-Marie Gerdes; Marie-José Roos-Blom; Flora van Leeuwen; Brita Arver; Håkan Olsson; Rita Schmutzler; Christoph Engel; Karin Kast; Kelly-Anne Phillips; Mary Beth Terry; Roger Milne; David Goldgar; Matti Rookus; Nadine Andrieu; Douglas Easton; kConFab Investigators

doi:10.1186/s13058-020-1247-4

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Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

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Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

Nasim Mavaddat, Antonis Antoniou, Thea Mooij, Maartje Hooning, Bernadette Heemskerk-Gerritsen, Catherine Noguès, Marion Gauthier-Villars, Olivier Caron, Paul Gesta, Pascal Pujol, …

Breast cancer research : BCR, Vol.22(1), pp.8-11

16/01/2020

DOI: https://doi.org/10.1186/s13058-020-1247-4

PMID: 31948486

Résumé

Cancer

Genetics

Human genetics

Life Sciences

Santé publique et épidémiologie

BACKGROUND:The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly for BRCA2 mutation carriers. Further, previous studies have not considered the effect of RRSO in the context of natural menopause.METHODS:A multi-centre prospective cohort of 2272 BRCA1 and 1605 BRCA2 mutation carriers was followed for a mean of 5.4 and 4.9 years, respectively; 426 women developed incident breast cancer. RRSO was modelled as a time-dependent covariate in Cox regression, and its effect assessed in premenopausal and postmenopausal women.RESULTS:There was no association between RRSO and breast cancer for BRCA1 (HR = 1.23; 95% CI 0.94-1.61) or BRCA2 (HR = 0.88; 95% CI 0.62-1.24) mutation carriers. For BRCA2 mutation carriers, HRs were 0.68 (95% CI 0.40-1.15) and 1.07 (95% CI 0.69-1.64) for RRSO carried out before or after age 45 years, respectively. The HR for BRCA2 mutation carriers decreased with increasing time since RRSO (HR = 0.51; 95% CI 0.26-0.99 for 5 years or longer after RRSO). Estimates for premenopausal women were similar.CONCLUSION:We found no evidence that RRSO reduces breast cancer risk for BRCA1 mutation carriers. A potentially beneficial effect for BRCA2 mutation carriers was observed, particularly after 5 years following RRSO. These results may inform counselling and management of carriers with respect to RRSO.

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Titre: Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers
Créateurs - sans rôle: Nasim Mavaddat - University of Cambridge [Cambridge, UK]
Antonis Antoniou - University of Cambridge [Cambridge, UK]
Thea Mooij - The Netherlands Cancer Institute
Maartje Hooning - Erasmus MC Cancer Institute
Bernadette Heemskerk-Gerritsen - Erasmus MC Cancer Institute, Rotterdam
Catherine Noguès - Institut Paoli-Calmettes
Marion Gauthier-Villars - Institut Curie [Paris]
Olivier Caron - Institut Gustave Roussy
Paul Gesta - Centre Hospitalier Georges Renon [Niort]
Pascal Pujol - Centre Hospitalier Régional Universitaire [Montpellier]
Alain Lortholary - Centre Catherine-de-Sienne [Nantes]
Daniel Barrowdale - University of Cambridge
Debra Frost - University of Cambridge [Cambridge, UK]
D. Gareth Evans - Manchester University NHS Foundation Trust
Louise Izatt - Guy's and St Thomas' NHS Foundation Trust
Julian Adlard - Chapel Allerton Hospital
Ros Eeles - Royal Marsden NHS Foundation Trust
Carole Brewer - Royal Devon University Healthcare NHS Foundation Trust
Marc Tischkowitz - University of Cambridge [Cambridge, UK]
Alex Henderson - Newcastle upon Tyne Hospitals NHS Foundation Trust
Jackie Cook - Sheffield Children's NHS Foundation Trust
Diana Eccles - Wessex Archaeology
Klaartje van Engelen - Vrije Universiteit Amsterdam
Marian Mourits - University Medical Center Groningen [Groningen]
Margreet Ausems - Department of Medical Genetics
Linetta Koppert - Erasmus MC Cancer Institute
John Hopper - The University of Melbourne
Esther John - Department of Epidemiology
Wendy Chung - Columbia University [New York]
Irene Andrulis - Departments of Molecular Genetics and Laboratory Medicine and Pathobiology
Mary Daly - Division of Population Science
Saundra Buys - Department of Internal Medicine
Javier Benitez - Departemento Genetica Humana
Trinidad Caldés - Instituto de Investigación Sanitaria del Hospital Clínico San Carlos [Madrid, Spain]
Anna Jakubowska - Department of Genetics and Pathology
Jacques Simard - Cancer Genomics Laboratory
Christian Singer - Division of Special Gynecology
Yen Tan - Medical University of Vienna
Edith Olah - National Institute of Oncology
Marie Navratilova - Masaryk Memorial Cancer Institute
Lenka Foretova - Masaryk University
Anne-Marie Gerdes - Department of Clinical Genetics [Copenhagen]
Marie-José Roos-Blom - The Netherlands Cancer Institute [Amsterdam, The Netherlands]
Flora van Leeuwen - The Netherlands Cancer Institute [Amsterdam, The Netherlands]
Brita Arver - Radiumhemmet
Håkan Olsson - Department of Oncology
Rita Schmutzler - Division of Molecular Gyneco-Oncology, Department of Gynaecology and Obstetrics, Clinical Center Un
Christoph Engel - Institute for Medical Informatics, Statistics and Epidemiology [Leipzig]
Karin Kast - Department of Gynaecology and Obstetrics
Kelly-Anne Phillips - Dept of Haematology and Medical Oncology
Mary Beth Terry - Department of Epidemiology [Columbia University]
Roger Milne - Cancer Epidemiology Centre
David Goldgar - International Agency for Cancer Research
Matti Rookus - Department of Epidemiology
Nadine Andrieu - Cancer et génome: Bioinformatique, biostatistiques et épidémiologie d'un système complexe
Douglas Easton - Cancer Research U.K. Genetic Epidemiology Unit
kConFab Investigators
Détails de publication: Breast cancer research : BCR, Vol.22(1), pp.8-11
Éditeur: BioMed Central
Identifiants: 99159118309311
Unité académique: Maladies Infectieuses et Vecteurs : Ecologie, Génétique, Evolution et Contrôle - MIVEGEC
Langue: English
Type de ressource: Journal article