Rhodium(I)-Catalyzed Borylation of Nitriles through the Cleavage of Carbon-Cyano Bonds

Mamoru Tobisu; Hirotaka Kinuta; Yusuke Kita; Emmanuelle Remond; Naoto Chatani

doi:10.1021/ja2095975

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Rhodium(I)-Catalyzed Borylation of Nitriles through the Cleavage of Carbon-Cyano Bonds

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Rhodium(I)-Catalyzed Borylation of Nitriles through the Cleavage of Carbon-Cyano Bonds

Mamoru Tobisu, Hirotaka Kinuta, Yusuke Kita, Emmanuelle Remond et Naoto Chatani

Journal of the American Chemical Society, Vol.134(1), pp.115-118

11/01/2012

DOI: https://doi.org/10.1021/ja2095975

PMID: 22185487

Résumé

Chemistry

Chemistry, Multidisciplinary

Physical Sciences

Science & Technology

The reaction of aryl cyanides with diboron in the presence of a rhodium/Xantphos catalyst and DABCO affords arylboronic esters via carbon-cyano bond cleavage. This unprecedented mode of reactivity for a borylrhodium species allows the regioselective introduction of a boryl group in a late stage of synthesis.

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Détails

Titre: Rhodium(I)-Catalyzed Borylation of Nitriles through the Cleavage of Carbon-Cyano Bonds
Créateurs - sans rôle: Mamoru Tobisu - Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
Hirotaka Kinuta - Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
Yusuke Kita - Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
Emmanuelle Remond - Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
Naoto Chatani - Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan
Détails de publication: Journal of the American Chemical Society, Vol.134(1), pp.115-118
Éditeur: Amer Chemical Soc
Nombre de pages: 4
Note de subvention: MEXT, Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
Identifiants: 99138901709311
Unité académique: Institut des Biomolécules Max Mousseron - IBMM
Langue: English
Type de ressource: Journal article